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1. 1. Glycolytic oscillations in individual yeast cells

   Författare :Anna-Karin Gustavsson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Optical manipulation; Microfluidics; Fluorescence microscopy; Single cell analysis; Saccharomyces cerevisiae; Glycolysis; Oscillations; NADH; Heterogeneity; Synchronization; Robustness; Universality;

   Sammanfattning : Oscillations in the concentration of yeast glycolytic intermediates have been intensively studied since the 1950s, but these studies have so far been limited to observations of average oscillatory behavior in synchronized cultures. Hence, it has remained unknown whether the onset of oscillations is a collective property of the population which requires a high cell density, or if individual cells can oscillate also in isolation. LÄS MER

3. 2. Tunable superconducting resonators, subharmonic oscillations and manipulation of microwaves

   Författare :Ida-Maria Svensson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; circuit-QED; tunable superconducting resonators; subharmonic oscillations; parametric oscillations; microwave manipulation; frequency down-conversion; driven nonlinear systems; superconducting resonator; SQUID; tunable resonator;

   Sammanfattning : In this thesis I present different types of manipulations of microwave fields using tunable superconducting resonators. A resonator is made tunable by adding one or more superconducting quantum interference devices, SQUIDs. The SQUID consists of a superconducting loop with two Josephson junctions and acts as a tunable nonlinear inductor. LÄS MER

4. 3. The Art of Modelling Oscillations and Feedback across Biological Scales

   Författare :Linnéa Gyllingberg; David J. T. Sumpter; Helen Byrne; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mathematical biology; mathematical modelling; oscillations; feedback mechanisms; dynamical systems; individual-based models; complex systems; Tillämpad matematik och statistik; Applied Mathematics and Statistics;

   Sammanfattning : This thesis consists of four papers in the field of mathematical biology. All papers aim to advance our understanding of biological systems through the development and application of innovative mathematical models. LÄS MER

5. 4. Single Cell Studies of Glycolytic Oscillations Using Microfluidics and Optical Tweezers

   Författare :Anna-Karin Gustavsson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Optical manipulation; microfluidics; fluorescence microscopy; single cell imaging; Saccharomyces cerevisiae; glycolysis; oscillations; NADH;

   Sammanfattning : The complex set of reactions in metabolism has been extensively studied in populations with millions of cells, but much information can still be gained by studying the heterogeneous metabolic behaviour in individual cells. The first part of energy metabolism is called glycolysis and is very similar in mammalian cells, such as human cells, and in yeast cells. LÄS MER

7. 5. On the Generation of cAMP Oscillations and Regulation of the Ca2+ Store-operated Pathway in Pancreatic Islet α- and β-cells

   Författare :Geng Tian; Erik Gylfe; Anders Tengholm; Patrick Gilon; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; oscillations; adrenaline; GLP-1; phosphodiesterase; palmitate; STIM1; Orai1; store-operated calcium entry; insulin secretion; glucagon secretion; β-cell; α-cell; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Insulin and glucagon are released in pulses from pancreatic β- and α-cells, respectively. Both cell types are electrically excitable, and elevation of the cytoplasmic Ca2+ concentration ([Ca2+]i) due to depolarization with voltage-dependent entry of the cation is the main trigger of hormone secretion. LÄS MER