Sökning: "orthogonal partial least squares"
Visar resultat 16 - 16 av 16 avhandlingar innehållade orden orthogonal partial least squares.
16. Molecular mechanisms and targets of new anticancer treatments
Sammanfattning : The work presented in this thesis is an effort to decipher and understand the mechanism of action (MOA) of anticancer agents by building on and complementing chemical proteomics methods. The backbone of the thesis relies on a recent method called Functional Identification of Target by Expression Proteomics (FITExP) developed in Zubarev lab, where drug induced proteomic signatures are analyzed in various cell lines and top differentially regulated proteins with consistent behavior are determined, among which the drug target and mechanistic proteins are usually present. LÄS MER
