Sökning: "ortho"

Visar resultat 11 - 15 av 68 avhandlingar innehållade ordet ortho.

  1. 11. Palladium(0)-Catalysed Carbonylative Multicomponent Reactions : Synthesis of Heterocycles and the Application of Quinolinyl Pyrimidines as Enzyme Inhibitors

    Författare :Linda Åkerbladh; Mats Larhed; Luke Odell; Anders Karlén; Lise-Lotte Gundersen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium catalysis; Carbonylation; Multicomponent reactions; Domino reactions; Heterocycles; 4-Quinolones; 2-Aminoquinazolinones; Benzoxazinones; N-Acylguanidines; Type II NADH dehydrogenase; NDH-2;

    Sammanfattning : Palladium-catalysed carbonylative multicomponent reactions have proven useful for the synthesis of structurally diverse compounds. Carbon monoxide serves as an atom-efficient, one-carbon building block, which allows for further structural elaboration of the carbonyl compound. LÄS MER

  3. 12. Analysis of PCBs with special emphasis on comprehensive two-dimensional gas chromatography of atropisomers

    Författare :Mikael Harju; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; PCB; Atropisomers; Chiral; GC×GC; Enantiomeric barriers; Seal; polar; shape selective; Cyclodextrin; 2D; ECD; FID; TOF-MS; Comprehensive two-dimensional GC; Miljökemi; Environmental chemistry; Miljökemi; analytisk kemi; Analytical Chemistry;

    Sammanfattning : There are 209 PCB congeners, 136 of which have been found in technical PCB mixtures and hence may be found in the environment as a result of either intentional or unintentional release. The identification and quantification of the congeners are difficult due to analytical bias from coeluting PCBs and other persistent organic pollutants. LÄS MER

  4. 13. In silico tools in risk assessment : of industrial chemicals in general and non-dioxin-like PCBs in particular

    Författare :Mia Stenberg; Patrik Andersson; Miriam Jacobs; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; industrial chemicals; in silico tools; molecular descriptors; non-dioxin-like PCBs; partial least-squares PLS ; principal component analysis PCA ; quantitative structure-activity relationship QSAR ; REACH; risk assessment RA ; statistical molecular design; structure-activity relationship SAR ;

    Sammanfattning : Industrial chemicals in European Union produced or imported in volumes above 1 tonne annually, necessitate a registration within REACH. A common problem, concerning these chemicals, is deficient information and lack of data for assessing the hazards posed to human health and the environment. LÄS MER

  5. 14. Transition Metal-Free O-, N- and S-Arylations with Diaryliodonium Salts

    Författare :Gabriella Kervefors; Berit Olofsson; Boris Nachtsheim; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amines; hypervalent iodine; electrophilic arylation; methodology development; total synthesis; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis concerns the development of metal-free arylation procedures using diaryliodonium salts, a non-toxic and versatile electrophilic arylating reagent, with applications to synthesize biologically relevant targets.The first part describes a transition metal-free formal synthesis of phenoxazine with an O-functionalization of a certain phenol as a key step. LÄS MER

  7. 15. Microwave-Assisted Synthesis of C2-Symmetric HIV-1 Protease Inhibitors : Development and Applications of In Situ Carbonylations and other Palladium(0)-Catalyzed Reactions

    Författare :Johan Wannberg; Anders Hallberg; David C. Rees; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV; protease inhibitors; palladium; carbonylations; molybdenum hexacarbonyl; dihydropyrimidone; DHPM; microwave; cross-coupling; diazylhydrazines; carbon monoxide; synthesis; C2-symmetric; HIV-1 protease inhibitors; aminocarbonylation; fluorous; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : The HIV protease is an essential enzyme for HIV replication and constitutes an important target in the treatment of HIV/AIDS. Efficient combination therapies using inhibitors of the reverse transcriptase and protease enzymes have led many to reevaluate HIV infections from a terminal condition to a chronic-but-manageable disease in the developed world. LÄS MER