Sökning: "organic view"

Visar resultat 1 - 5 av 102 avhandlingar innehållade orden organic view.

  1. 1. Carbocation Catalysis for Organic Synthesis

    Författare :Shengjun Ni; Johan Franzén; Bernd Plietker; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbocation; trityl cation; Lewis acid catalyst; enantioselective; chiral counteranion; oxa-Diels–Alder; bromination; aldehyde–olefin metathesis; Kemi; Chemistry;

    Sammanfattning : The most common view of carbocations in organic chemistry is that they are short-lived intermediates in several fundamental reactions, e.g. the classic SN1-reaction. LÄS MER

  3. 2. Palladium-Catalysed Couplings in Organic Synthesis : Exploring Catalyst-Presenting Strategies and Medicinal Chemistry Applications

    Författare :Alejandro Trejos; Mats Larhed; Jianliang Xiao; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mizoroki-Heck arylation; Suzuki coupling; domino reaction; stereoselective; palladium; chelation control; vinyl ether; HIV-protease inhibitors; HIV-integrase inhibitors; Kemi med inriktning mot organisk kemi; Chemistry with specialization in Organic Chemistry;

    Sammanfattning : Palladium-catalysed coupling reactions have been embraced by synthetic chemists as one of the preferred means for smooth formation of new carbon-carbon bonds: a truly ubiquitous methodology of synthesizing complex molecules.This thesis describes the study of a series of palladium(0)-catalysed C2-arylations of a 1-cyclopentenyl ether, equipped with a chiral (S)-N-methyl-pyrrolidine auxiliary. LÄS MER

  4. 3. Development and Applications of Hypervalent Iodine Compounds : Powerful Arylation and Oxidation Reagents

    Författare :Nazli Jalalian; Berit Olofsson; Viktor V. Zhdankin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hypervalent iodine compounds; diaryliodonium salts; oxidation; Koser s reagent; arylation; phenols; diaryl ethers; chemoselectivity; organisk kemi; Organic Chemistry;

    Sammanfattning : The first part of this thesis describes the efficient synthesis of several hypervalent iodine(III) compounds. Electron-rich diaryliodonium salts have been synthesized in a one-pot procedure, employing mCPBA as the oxidant. Both symmetric and unsymmetric diaryliodonium tosylates can be isolated in high yields. LÄS MER

  5. 4. Synthetic studies of rigid tetracyclic oxanorbornanes. Regioselective reductive Heck arylation of a tetracyclic scaffold

    Författare :Andreas Wållberg; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; oxanorbornane; rigid; Heck-reaction; regioselective; Organisk kemi;

    Sammanfattning : Rigid or conformationally restricted compounds are intresting from a pharmacological point of view since they do not have to pay the entropy penalty paid by more flexible molecules in binding to e.g. a protein. LÄS MER

  7. 5. Chemical attenuation of bacterial virulence : small molecule inhibitors of type III secretion

    Författare :Anna Kauppi; Mikael Elofsson; Anders Karlén; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; Organic chemistry; Organisk kemi;

    Sammanfattning : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. LÄS MER