Sökning: "organic S"

Visar resultat 21 - 25 av 361 avhandlingar innehållade orden organic S.

1. 21. Mechanisms for Solvolytic Elimination and Substitution Reactions Involving Short-lived Carbocation Intermediates

   Författare :Xiaofeng Zeng; Einar Uggerud; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : Solvolysis reactions of a range of tertiary substrates in largely aqueous solvents were studied in such respects as β-deuterium kinetic isotope effects, linear free energy relationships and stereochemistry.Solvolysis of the fluorene derivatives 9-methyl–9-(2´-X-2´-propyl)fluorene (1-X, X = Cl, Br, OOCCF3) involves a very short-lived carbocation intermediate. LÄS MER

3. 22. Design and Synthesis of Amine Building Blocks and Protease Inhibitors

   Författare :Susana Ayesa Alvarez; Bertil Samuelsson; Thomas Olsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

   Sammanfattning : The first part of this thesis addresses the design and synthesis of amine building blocks accomplished by applying two different synthetic procedures, both of which were developed using solid-phase chemistry. Chapter 1 presents the first of these methods, entailing a practical solid-phase parallel synthesis route to N-monoalkylated aminopiperidines and aminopyrrolidines achieved by selective reductive alkylation of primary and/or secondary amines. LÄS MER

4. 23. Synthetic and Mechanistic Studies with Iodine(III) Reagents

   Författare :Ester Maria Di Tommaso; Berit Olofsson; Marcos Suero; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hypervalent iodine chemistry; organic synthesis; mechanistic studies; DFT; photocatalysis; Organic Chemistry; organisk kemi;

   Sammanfattning : This thesis describes the development of metal-free transformations and mechanistic studies on the reactivity of two classes of hypervalent iodine reagents: diaryliodonium salts and vinylbenziodoxolones (VBX). Recently, they have been recognized as valuable synthetic reagents with broad applicability in organic synthesis. LÄS MER

5. 24. Design & Synthesis of Protein Interacting Affinity Ligands and Protease Inhibitors

   Författare :Charlotta Lindquist; Hans Adolfsson; Fredrik Almqvist; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

   Sammanfattning : There is a growing need of both protein drugs and synthetic drugs in the fight against many life-threatening diseases. The first part of this thesis deals with the design and synthesis of high affinity binding ligands for the purification of protein drugs. LÄS MER

7. 25. Synthesis of Carbohydrate Mimics and Development of a Carbohydrate Epimerisation Method

   Författare :Clinton Ramstadius; Ian Cumpstey; Robert Madsen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrate Mimic; Ring-closing Metathesis; Carbohydrate Chemistry; Carbasugar; Aminocarbasugar; Pseudodisaccharide; Glycosidase and Lectin Inhibitors; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : In this thesis the synthesis of several hydrolytically stable carbohydrate mimics with the potential to function as glycosidase or lectin inhibitors are described. This work is presented in Chapters 2-5. LÄS MER