Sökning: "organelle purification"

Hittade 4 avhandlingar innehållade orden organelle purification.

  1. 1. Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function

    Författare :Anders Wittrup; Bröstca-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LL-37; heparan sulfate; glypican; endocytosis; drug delivery; DNA uptake; Cancer; cell penetrating peptides; non-viral gene delivery; organelle purification; proteoglycan; syndecan.;

    Sammanfattning : Novel therapeutics to combat cancer are urgently needed. Most current pharmacological therapies have severe side effects and are seldom curative. Macromolecular drugs, and in particular nucleic acid based drugs, offer a potential remedy for this situation. LÄS MER

  2. 2. Hidden Diversity Revealed : Genomic, Transcriptomic and Functional Studies of Diplomonads

    Författare :Jon Jerlström-Hultqvist; Staffan Svärd; Adrian Hehl; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Giardia intestinalis; Spironucleus salmonicida; Spironucleus barkhanus; intestinal parasite; hydrogenosome; mitosome; lateral gene transfer; horizontal gene transfer; diplomonad; metamonad; sexual recombination; transfection; protein complex purification; Biology with specialization in Evolutionary Organismal Biology; Biologi med inriktning mot evolutionär organismbiologi; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Sammanfattning : The diplomonads are a diverse group of eukaryotic microbes found in oxygen limited environments such as the intestine of animals were they may cause severe disease. Among them, the prominent human parasite Giardia intestinalis non-invasively colonizes the small intestine of humans and animals where it induces the gastrointestinal disease giardiasis. LÄS MER

  3. 3. From Sequence to Structure- Characterizing Human and Plant Aquaporins

    Författare :Kristina Nordén; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Aquaporins constitute a class of membrane proteins that create pores through the lipid bilayer of biological membranes, facilitating the passage of water and other small solutes. Nearly all living organisms possess a more or less intricate set up of aquaporin proteins and the importance of these channels has been implicated in many aspects of health and disease. LÄS MER

  4. 4. Spatiotemporal characterization of the human proteome

    Författare :Diana Mahdessian; Emma Lundberg; Arne Lindqvist; KTH; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Spatial proteomics; Spatiotemporal proteomics; Immunofluorescence; Human Protein Atlas; Cell compartments; Single cell proteomics; Cell cycle; Cancer;

    Sammanfattning : Characterizing the molecular components of the basic unit of life; the cell, is crucial for a complete understanding of human biology. The cell is divided into compartments to create a suitable environment for the resident proteins to fulfill their functions. LÄS MER