Sökning: "organ injury"

Visar resultat 1 - 5 av 157 avhandlingar innehållade orden organ injury.

1. 1. Injury-Induced Signalling in Arterial Smooth Muscle Cells

   Författare :Sara Moses; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GAG; Clinical biology; Klinisk biologi; proteoglycan; osteopontin; ERK; MAPK; signalling; smooth muscle cell; injury;

   Sammanfattning : The vascular wall is an active, elastic and integrated organ made up of cellular and extracellular matrix (ECM) components. It is not a static organ; the components dynamically change and reorganize in response to physiological and pathological stimuli. Vascular injury induces a complex healing process, analogous to generalised wound healing. LÄS MER

3. 2. Pancreatitis-Associated Pulmonary Injury

   Författare :Xia Zhao; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; orthopaedics; Surgery; inflammatory mediators; protein kinase C; leukocytes; acute lung injury; abdominal sepsis; acute pancreatitis; traumatology; Kirurgi; ortopedi; traumatologi;

   Sammanfattning : In acute pancreatitis (AP), lung injury is an early occuring and important part of the multiple organ dysfunction syndrome. The mechanisms underlying the development of lung injury though still largely remains unclear. LÄS MER

4. 3. Definition of axonal injury tolerances across scales : A computational multiscale approach

   Författare :Annaclaudia Montanino; Svein Kleiven; Alessandra Villa; Xiaogai Li; Kacy Cullen; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Traumatic Brain Injury; Axonal Injury; Mechanoporation; Multiscale;

   Sammanfattning : Traumatic brain injury (TBI) is today regarded as a global health challenge. Revealing how external mechanical loads translate into tissue and cellular damage is necessary, not only for the development of better preventive measures, but also for the definition of treatments that could spare the patients from suffering TBI's devastating consequences. LÄS MER

5. 4. Pulmonary Injury Following Intestinal Ischemia and Reperfusion in Rats

   Författare :Anna Börjesson; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reperfusion injury; intestinal ischemia; pulmonary injury; endothelium; cytokines; alveolar fluid clearance; leukocytes; orthopaedics; Surgery; traumatology; ortopedi; Kirurgi; traumatologi;

   Sammanfattning : Intestinal ischemia and reperfusion (I/R) is a potentially life-threatening condition, sometimes leading to a systemic inflammatory response and the potential development of the multiple organ dysfunction syndrome. The overall aim of the thesis was to study the effects of intestinal I/R on pulmonary function with special emphasis on removal of excess alveolar fluid, pulmonary endothelial barrier permeability, leukocyte accumulation and function, and possible therapeutic strategies to prevent the development of pulmonary injury following intestinal I/R. LÄS MER

7. 5. Acute pancreatitis, from local defense to remote organ injury

   Författare :Hamid Akbarshahi; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute pancreatitis; heparan sulfate; damage associated molecular patterns; toll-like receptor4; MyD88; IRF-3; acute lung injury; macrophages; transforming growth factor-beta; Smad;

   Sammanfattning : Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications such as acute lung injury (ALI). LÄS MER