Sökning: "oral anticoagulants"

Visar resultat 21 - 25 av 34 avhandlingar innehållade orden oral anticoagulants.

  1. 21. Management of hemorrhagic complications associated with antithrombotic therapy

    Författare :Ammar Majeed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Anticoagulants are used for the prevention and treatment of arterial and venous thromboembolism. Such therapy is always associated with an increased risk of bleeding. Intracranial hemorrhage is the most serious form of anticoagulantsrelated bleeding and caries a high mortality rate. LÄS MER

  3. 22. Drug safety and effectiveness in relation to kidney function : a pharmacoepidemiological approach

    Författare :Marco Trevisan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kidney function plays an important role in drug safety and effectiveness. As many medications are excreted by the kidneys, patients with reduced kidney function are at a higher risk of supra-therapeutic or toxic drug levels. LÄS MER

  4. 23. On the Prediction of Warfarin Dose

    Författare :Niclas Eriksson; Mia Wadelius; Lars Wallentin; Lars Berglund; Patrik Magnusson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Warfarin; pharmacogenetics; prediction models; Dosing algorithm; GWAS; VKORC1; CYP2C9; Clinical Pharmacology; Klinisk farmakologi;

    Sammanfattning : Warfarin is one of the most widely used anticoagulants in the world. Treatment is complicated by a large inter-individual variation in the dose needed to reach adequate levels of anticoagulation i.e. INR 2. LÄS MER

  5. 24. Sex and gender aspects in drug utilization

    Författare :Desirée Loikas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drug prescribing is one of the most important processes in healthcare and drugs are also commonly used in the population. Drug use differs between men and women and descriptive reports of sex differences in drug use have been published with examples from different therapeutic areas. LÄS MER

  7. 25. Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9

    Författare :Mia Sandberg Lundblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochromes P450 (CYP) are enzymes, mainly catalysing the oxidation of xenobiotics, in order to facilitate their excretion from the body. CYP2C9 is a polymorphic enzyme, which is responsible for the metabolism of about 10 % of all known drugs, e. LÄS MER