Sökning: "optogenetics"

Visar resultat 6 - 10 av 18 avhandlingar innehållade ordet optogenetics.

  1. 6. On the Mechanisms Behind Hippocampal Theta Oscillations : The role of OLMα2 interneurons

    Författare :Sanja Mikulovic; Richardson Leao; Klas Kullander; Stefan Remy; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hippocampus; interneuron; optogenetics; theta oscillations; anxiety;

    Sammanfattning : Theta activity is one of the most prominent rhythms in the brain and appears to be conserved among mammals.  These 4-12 Hz oscillations have been predominantly studied in the dorsal hippocampus where they are correlated with a broad range of voluntary and exploratory behaviors. LÄS MER

  3. 7. Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation

    Författare :Caroline Miranda; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Glucagon; α-Cell; Optogenetics;

    Sammanfattning : ABSTRACT The mechanisms controlling glucagon secretion by α-cells in islets of Langerhans were studied. We generated mice with the light-activated ion channel ChR2 specifically expressed in β-, α-, and δ-cells, and explored the spatio-temporal relationship between cell activation and glucagon release. LÄS MER

  4. 8. Phosphoinositides control insulin secretion through multiple routes

    Författare :Phuoc My Nguyen; Christina Bark; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phosphoinositides; PI 4 P; PI 4; 5 P2; Ca2 ; optogenetics; VDCC; Sac2; OSBP; OSW-1; cholesterol; membrane contact sites;

    Sammanfattning : Glucose-stimulated insulin secretion from pancreatic beta cells is the sequence of events that starts with glucose uptake and ends with the fusion of insulin granules with the plasma membrane through Ca2+-triggered exocytosis. Phosphoinositides are minor components of all cellular membranes, yet play fundamental roles as regulators of many cellular processes. LÄS MER

  5. 9. Evolution of acetylcholine receptors and study of the anatomy of the mouse brain reward system

    Författare :Julia Pedersen; Dan Larhammar; Arnaud Chatonnet; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ventral Tegmental Area; Mesocorticolimbic system; Glutamate; Optogenetics; Histology; Acetylcholine; Receptor; Muscarininc; Nicotinic; G protein-coupled receptor; Gene duplication; Tetraploidization; Synteny; Paralogon; Ohnolog; Zebrafish; Spotted gar; Neuroscience; Neurovetenskap;

    Sammanfattning : This thesis work is divided in two parts. In the first part, I make use of the transgenic TRPV1-Cre mouse line as a tool to investigate the midbrain ventral tegmental area (VTA). LÄS MER

  7. 10. Gene Therapy for Neurological Disorders

    Författare :Jan Tönnesen; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epileptiform activity; striatum; organotypic culture; electrophysiology; Wnt5a; synaptic connectivity.; cell transplantation; hippocampus; neural stem cells; epilepsy; functional integration; Parkinson’s disease; optogenetics; Gene therapy;

    Sammanfattning : Gene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. LÄS MER