Avancerad sökning

Visar resultat 1 - 5 av 18 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry

   Författare :Fredrik Berglind; Epilepsicentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Seizure; epileptogenesis; optogenetics; NpHR; ChR2; DREADD; hippocampus; in vivo; mouse;

   Sammanfattning : Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmaceuticals. LÄS MER

3. 2. The subthalamic nucleus in motor and affective functions : An optogenetic in vivo-investigation

   Författare :Adriane Guillaumin; Åsa Wallén-Mackenzie; Konstantinos Meletis; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Subthalamic nucleus; optogenetics; basal ganglia; locomotion; Parkinson s disease; aversion; Neuroscience; Neurovetenskap;

   Sammanfattning : The basal ganglia form a group of subcortical interconnected nuclei involved in motor, limbic and cognitive functions. According to the classical model of the basal ganglia, two main pathways exert opposing control over movement, one facilitating movement and the other suppressing movement. LÄS MER

4. 3. United in Diversity : A Physiological and Molecular Characterization of Subpopulations in the Basal Ganglia Circuitry

   Författare :Thomas Viereckel; Åsa Wallén-Mackenzie; Åsa Konradsson-Geuken; Erika Comasco; Per Svenningsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Glutamate; Optogenetics; Amperometry; Histology; Midbrain; Subthalamic Nucleus; Parkinson s disease; Ventral Tegmental Area; Substantia Nigra; Co-release;

   Sammanfattning : The Basal Ganglia consist of a number of different nuclei that form a diverse circuitry of GABAergic, dopaminergic and glutamatergic neurons. This complex network is further organized in subcircuits that govern limbic and motor functions in humans and other vertebrates. LÄS MER

5. 4. Motion and Emotion : Functional In Vivo Analyses of the Mouse Basal Ganglia

   Författare :Emma Arvidsson; Åsa Wallén-Mackenzie; Cecilia Flores; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine; Basal Ganglia; Reward System; In Vivo Chronoamperometry; Optogenetics; Deep Brain Stimulation; Parkinson’s Disease; Addiction; Glutamate; Vesicular Glutamate Transporter; VGLUT2; Sex; Age; Subthalamic Nucleus; Striatum; Nucleus Accumbens; Ventral Tegmental Area;

   Sammanfattning : A major challenge in the field of neuroscience is to link behavior with specific neuronal circuitries and cellular events. One way of facing this challenge is to identify unique cellular markers and thus have the ability to, through various mouse genetics tools, mimic, manipulate and control various aspects of neuronal activity to decipher their correlation to behavior. LÄS MER

7. 5. Endogenous modulators of hyperexcitability in epilepsy: electrophysiological and optogenetic delineation of neuropeptide Y mechanisms in interneurons

   Författare :Marco Ledri; Lund Neurologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; interneurons; Epilepsy; Neuropeptide Y; synaptic transmission; synaptic plasticity; electrophysiology; optogenetics;

   Sammanfattning : Epilepsy is one of the most common neurological disorders worldwide, affecting 1% of the general population, and is characterized by a predisposition for the generation of epileptic seizures. Despite having several different aetiologies, a common underlying cause of epilepsy seems to be an acquired imbalance between excitatory and inhibitory circuits in the brain, which leads to hyperexcitability and appearance of seizures. LÄS MER