Sökning: "optimal design"

Visar resultat 21 - 25 av 1009 avhandlingar innehållade orden optimal design.

  1. 21. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications

    Författare :Charles Ernest II; Andrew Hooker; Mats Karlsson; Bart Ploeger; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; population models; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). LÄS MER

  3. 22. Test Design for Mean Ability Growth and Optimal Item Calibration for Achievement Tests

    Författare :Jonas Bjermo; Frank Miller; Marie Wiberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; test design; item response theory; optimal experimental design; SweSAT; item calibration; vertical scaling; ability growth; computerized adaptive tests; Statistics; statistik;

    Sammanfattning : In this thesis, we examine two topics in the area of educational measurement. The first topic studies how to best design two achievement tests with common items such that a population mean-ability growth is measured as precisely as possible. The second examines how to calibrate newly developed test items optimally. LÄS MER

  4. 23. Optimal input design for nonlinear dynamical systems : a graph-theory approach

    Författare :Patricio E. Valenzuela Pacheco; Cristian R. Rojas; Roland Hildebrand; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Input design; Markov chains; system identification; Electrical Engineering; Elektro- och systemteknik;

    Sammanfattning : Optimal input design concerns the design of an input sequence to maximize the information retrieved from an experiment. The design of the input sequence is performed by optimizing a cost function related to the intended model application. Several approaches to input design have been proposed, with results mainly on linear models. LÄS MER

  5. 24. Diffractive Optics Design

    Författare :Jörgen Bengtsson; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; computer-generated waveguide hologram; diffractive optics; fan-out; millimeter wave radiation; proximity effect; optimal-rotation-angle method; kinoform; integrated optics; beam shaping; outcoupling grating; scalar optics;

    Sammanfattning : Diffractive optical elements (kinoforms) change the way light propagates, and can perform very complex tasks. They can split an incident beam into any number of outgoing, and possibly focused, beams (fan-out). LÄS MER

  7. 25. Viscoelastic Materials : Identification and Experiment Design

    Författare :Agnes Rensfelt; Torsten Söderström; Händel Peter; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; viscoelastic materials; complex modulus; system identification; optimal experiment design; distributed parameter systems; frequency domain identification; wave propagation; Automatic control; Reglerteknik; Elektroteknik med inriktning mot reglerteknik; Electrical Engineering with specialization in Automatic Control;

    Sammanfattning : Viscoelastic materials can today be found in a wide range of practical applications. In order to make efficient use of these materials in construction, it is of importance to know how they behave when subjected to dynamic load. LÄS MER