Sökning: "opioid dependence"

Visar resultat 11 - 15 av 37 avhandlingar innehållade orden opioid dependence.

1. 11. Understanding Opioid Therapy in Chronic Pain : Assessment, Lived Experience and Conceptions

   Författare :Hanna Ljungvall; Pernilla Åsenlöf; Nitya Jayaram-Lindström; Uppsala universitet; []
   Nyckelord :;

   Sammanfattning : The overarching aim of this thesis was to improve the understandings of opioid therapy for chronic non-cancer pain (CNCP) by examining the feasibility of different assessment methods of substance use, and opioid use disorder (OUD), and exploring the sense-making of opioid therapy in CNCP.  Methods: In study I, the reliability of the Addiction Severity Index Self-Report form (ASI-SR) was assessed by the agreement (intraclass correlation (ICC)) between the composite scores (CS) of the ASI interview and the ASI-SR, internal consistency of the CS subscales measured with Cronbach’s α, and sensitivity and specificity of the alcohol and drug CS’s, using Receiver Operating Characteristics analyses. LÄS MER

3. 12. Characterization of Substance P (SP) Aminoterminal SP (1-7) Binding in Brain Regions and Spinal Cord of the Male Rat : Studies on the Interaction with Opioid Related Pathways

   Författare :Milad Botros; Fred Nyberg; Tsukasa Sakurada; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Biologisk beroendeforskning;

   Sammanfattning : Binding sites for substance P(1-7), SP(1-7) have been identified and characterized for the first time in crude membrane fraction from rat CNS using tritiated ([3H]) SP(1-7) as tracer. These putative receptors were investigated in relation to their affinity for tachykinins, opioid peptides and sigma receptor ligands. LÄS MER

4. 13. En dyster parentes – opiatregeln i svensk LARO-behandling 2010–2016

   Författare :Bodil Monwell; Arne Gerdner; Björn Johnson; Per Bülow; Thomas Clausen; Jönköping University; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; opiates; opioids; opioid maintenance treatment; methadone; buprenorphine; regulation; National Board of Health and Welfare; opiater; opioider; opioidberoende; buprenorfin; metadon; läkemedelsassisterad behandling; föreskrift; Socialstyrelsen;

   Sammanfattning : Opioids are well documented to arouse euphoria, relieve pain, and to have a high dependency potential. Opioid dependence is a serious chronic condition with a high risk of extensive worsened health, relapse and premature death.Opioid maintenance treatment (OMT) is well researched and has strong scientific support. LÄS MER

5. 14. The Impact of Nandrolone Decanoate on Neuropeptidergic Mechanisms Related to Cognition, Aggression, Reward and Dependence

   Författare :Kristina Magnusson; Fred Nyberg; Mathias Hallberg; Santi Mario Spampinato; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anabolic androgenic steroids; Nandrolone decanoate; Substance P; Dynorphin A; KOP receptor; Prodynorphin; Radioimmunoassay; Autoradiography; Morris water maze; PCR; Central nervous system; Biological research on drug dependence; Biologisk beroendeforskning; Biological Research on Drug Dependence; Biologisk beroendeforskning;

   Sammanfattning : The abuse of anabolic androgenic steroids (AAS) is becoming increasingly common and may result in a range of physiological as well as psychological effects such as altered behavior in terms of increased aggression, cognitive dysfunction and addictive behavior. AAS comprise testosterone and its derivatives, of which nandrolone is one of the more common. LÄS MER

7. 15. Brain opioid mechanisms in amphetamine induced behaviours

   Författare :Jenny Häggkvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Amphetamine abuse and dependence are global health problems, affecting large numbers of individuals. Despite extensive research efforts, there has been no evidence-based pharmacotherapy available for amphetamine dependence. LÄS MER