Sökning: "ontogeny"

Visar resultat 21 - 25 av 88 avhandlingar innehållade ordet ontogeny.

1. 21. The ontogeny and function of intestinal dendritic cells

   Författare :Emma Persson; Slemhinnans immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mesenteric lymph nodes; Intestine; Dendritic cells; Gut-homing; Th17 cells; Oral tolerance; Immunity;

   Sammanfattning : The intestinal mucosa presents a huge surface area to the external environment and the intestinal immune system is continually exposed to a wide array of foreign antigens derived from resident intestinal microbiota as well as dietary constituents, including food proteins. In order to maintain intestinal homeostasis, the intestinal immune system relies on the ability to generate tolerogenic responses to innocuous antigen while maintaining the ability to develop effective immune responses to intesinal pathogens. LÄS MER

3. 22. The ontogeny and regulation of human natural killer cells

   Författare :Martin A Ivarsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Natural Killer (NK) cells are members of the innate lymphoid cell (ILC) family and take part in the detection and eradication of virus-infected and transformed cells. In this thesis, together with my colleagues I have investigated how NK cells and other ILCs develop and function during human fetal development, how NK cells are functionally regulated (educated) via the activating receptor KIR2DS1, and how NK cells in our body are affected during the early phase of an acute viral infection. LÄS MER

4. 23. From wolf to dog: Behavioural evolution during domestication

   Författare :Christina Hansen Wheat; Hans Temrin; Clive Wynne; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Domestication syndrome; behavioural evolution; behaviorual ontogeny; correlated traits; sociability; playfulness; aggression; fear; Canis familiaris; Canis lupus; artificial selection; etologi; Ethology;

   Sammanfattning : Biologists since Darwin have recognized that domestication, where species are selected to live in human-controlled environments, exerts strong selection on organisms and dramatically impacts their evolutionary trajectories. Across domesticated mammal species, characteristic morphological, physiological and behavioural changes occur simultaneously, as correlated traits, a phenomenon known as the domestication syndrome. LÄS MER

5. 24. T Cell Ontogeny and Effector Functions in Galphai2-deficient Colitis

   Författare :Malin Bjursten; Göteborgs universitet; []
   Nyckelord :colitis; T cells; Galphai2- - mice; thymus; pro-inflammatory cytokines; alpha4 integrin;

   Sammanfattning : Inflammatory bowel disease (IBD) comprising Crohn s disease and ulcerative colitis is a disease that affects millions of people worldwide, especially in northern countries such as Sweden, and is characterised by chronic uncontrolled inflammation of the intestinal mucosa. It is the general belief that multiple factors such as genetic and environmental aspects are involved in disease pathogenesis. LÄS MER

7. 25. Ontogeny of perception of maternal and nosocomial stimuli in infants

   Författare :Jakob Frie; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Preterm born infants in neonatal units experience unusual sensory inputs that can shape and nurture their developing brains differently from full-term healthy newborn infants. To improve the care of preterm infants and their neurodevelopmental outcomes, we need to understand how the brain functions at different developmental stages and implement this knowledge into clinical care and follow-up programs. LÄS MER