Sökning: "oligodendroglia"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet oligodendroglia.

  1. 1. On age related changes in axons and glia of the central nervous system

    Författare :Susanna Kullberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aging; synaptic input; spinal cord; hippocampus; amino acid neurotransmitters; astrocyte; microglia; oligodendroglia; C bouton; cholinergic; monoaminergic; cytokine;

    Sammanfattning : A growing body of evidence shows that phenotypic changes including axon aberrations, rather than loss of neurons, account for behavioral impairments during aging. The present thesis was undertaken to investigate the occurrence of axon aberrations in relation to transmitter identity, glial reaction and sensorimotor disturbances. LÄS MER

  3. 2. Gene regulatory mechanisms in the oligodendrocyte lineage in development and disease

    Författare :Mandy Meijer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They contribute to the neuronal network through the insulation of neuronal axons, facilitating communication between neurons and providing metabolic support. LÄS MER

  4. 3. Oligodendroglial (dys)function in alpha-synucleinopathies

    Författare :Carla Azevedo; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synucleinopathies; iPSCs; oligodendrocytes; alpha-synuclein; HLA; cell maturation; immunoproteasome;

    Sammanfattning : The complexity of a-synucleinopathies, which include multiple system atrophy (MSA) and Parkinson’s disease (PD), is not entirely understood. It is known that pathological accumulation of a-synuclein (a-syn) into proteinaceous aggregates is a cellular hallmark of these diseases. LÄS MER

  5. 4. The type IV Oligodendrocyte : experimental studies on chicken white matter

    Författare :Emma S. Anderson; Arthur M. Butt; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : In mammals, islet amyloid polypeptide (IAPP) is co-produced with insulin in pancreatic ß-cells. In the chicken, the expression of IAPP in the brain is more than 10-fold higher than in the pancreas. LÄS MER

  7. 5. Functional studies of the Quaking gene : Focus on astroglia and neurodevelopment

    Författare :Katarzyna Radomska; Elena Jazin; Pertti Panula; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; QKI; RNA-binding protein; astrocyte; interferon; GFAP; neurodevelopment; zebrafish; neural progenitor cell;

    Sammanfattning : The RNA-binding protein Quaking (QKI) plays a fundamental role in post-transcriptional gene regulation during mammalian nervous system development. QKI is well known for advancing oligodendroglia differentiation and myelination, however, its functions in astrocytes and embryonic central nervous system (CNS) development remain poorly understood. LÄS MER