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Visar resultat 1 - 5 av 59 avhandlingar som matchar ovanstående sökkriterier.

1. 1. The type IV Oligodendrocyte : experimental studies on chicken white matter

   Författare :Emma S. Anderson; Arthur M. Butt; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : In mammals, islet amyloid polypeptide (IAPP) is co-produced with insulin in pancreatic ß-cells. In the chicken, the expression of IAPP in the brain is more than 10-fold higher than in the pancreas. LÄS MER

3. 2. Oligodendrocyte pathology following Traumatic Brain Injury : Experimental and clinical studies

   Författare :Johanna Flygt; Niklas Marklund; Fredrik Piehl; Uppsala universitet; []
   Nyckelord :Traumatic brain injury; oligodendrocytes; oligodendrocyte progenitor cells; interleukin 1-β; central fluid percussion injury; Neurokirurgi; Neurosurgery; Neurokirurgi; Neurosurgery;

   Sammanfattning : Traumatic brain injury (TBI) caused by traffic and fall accidents, sports-related injuries and violence commonly results in life-changing disabilities. Cognitive impairments following TBI may be due to disruption of axons, stretched by the acceleration/deceleration forces of the initial impact, and their surrounding myelin in neuronal networks. LÄS MER

4. 3. Translational research of the quaking gene : Focusing on the conjunction between development and disease

   Författare :Bryn Farnsworth; Lina Emilsson; Roman Chrast; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; QKI; glia; oligodendrocyte; Alzheimer s; schizophrenia; zebrafish; statistics; morpholino; Biologi med inriktning mot evolutionär organismbiologi; Biology with specialization in Evolutionary Organismal Biology;

   Sammanfattning : Quaking (QKI) is an RNA binding protein involved in the post-transcriptional regulation of gene expression. Originally identified as the cause of hypomyelination in a mouse mutant, it has since been consistently implicated in a wide range of neurological diseases. LÄS MER

5. 4. Cell states along oligodendrocyte development and disease

   Författare :David van Bruggen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The brain, one of the most complex organs in the body, where an immense diversity of cell states emerges from simple structure, where function arises from sets of regulatory principles and pattern persist where individual cells do not. Revealing the regulatory underpinnings of the brain, from unspecified cell states to diversity, is paramount for achieving a thorough understanding of the development process and generating insight into the disease states of the brain. LÄS MER

7. 5. Post-translational modifications of myelin oligodendrocyte glycoprotein in CNS autoimmunity

   Författare :Andreas Warnecke; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Autoimmunity towards components of the central nervous system (CNS) is a driving factor of nerve demyelination in Multiple Sclerosis (MS). The etiology of autoimmunity in MS pathogenesis remains elusive, but a combination of genetic predisposition and environmental triggers is theorized to initiate this complex disease. LÄS MER