Sökning: "olefination"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet olefination.

1. 1. Transition Metal Mediated Transformations of Carboranes

   Författare :Ludvig Eriksson; Kalman Szabo; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; carborane; isoquinoline; PK11195; peripheral bensodiazepine receptor; Cu I Iodide; iodinated carborane; palladium; isotopic exchange; Herrmann’s Catalyst; Heck reaction; Suzuki-Miyaura reaction; cross coupling; arylation; olefination; 125-iodine; radiolabelling; carboraneboronic ester; BNCT; 2-iodo-; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis describes the use of copper and palladium to mediate transformations of carboranes, especially p-carborane.1-(1-p-carboranyl)-N-methyl-N-(2-butyl)-3-isoquinolinecarboxamide, a carborane containing analogue of the peripheral benzodiazepine receptor (PBR) ligand PK11195, has been synthesised. LÄS MER

3. 2. Methods for Asymmetric Olefination Reactions; Development and Application to Natural Product Synthesis

   Författare :Daniel Strand; Tobias Rein; Viresh Rawal; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antitumor agents; Asymmetric Horner-Wadsworth-Emmons; Desymmetrization; Metal-catalyzed olefination; Mucocin; Palladium-catalyzed allylic substitution; Parallel kinetic resolution; Pyranicin; Pyragonicin; Rhenium; Stereoconvergent synthesis; Stereodivergent synthesis; Stereoselective synthesis; Tetrahydropyran; Wittig reaction; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis deals with the development and application of methods for asymmetric olefinations, in particular Horner-Wadsworth-Emmons (HWE) reactions, in the synthesis of certain natural products. Relying on asymmetric HWE reactions to access key building blocks, two natu-ral products, pyranicin and pyragonicin, were synthesized from common late intermediates. LÄS MER

4. 3. Development of Asymmetric Iridium Catalysed Hydrogenation Reactions

   Författare :Suppachai Krajangsri; Pher Andersson; Patrick Guiry; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Asymmetric hydrogenation; Iridium catalyst; Peterson olefination; Dynamic Kinetic Resolution; organisk kemi; Organic Chemistry;

   Sammanfattning : The focus of the work presented in this thesis is the development of iridium-catalysed asymmetric hydrogenation reactions.The first part of this thesis covers the development of dynamic kinetic resolution in asymmetric hydrogenation of chiral, racemic secondary allylic alcohols, which are converted to chiral saturated alcohols with high dr and ee. LÄS MER

5. 4. Bridging McMurry and Wittig in One-Pot : Olefins from Stereoselective, Reductive Couplings of Two Aldehydes via Phosphaalkenes

   Författare :Juri Mai; Sascha Ott; Christian Müller; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbonyl olefination; reductive aldehyde coupling; stereoselective; organophosphorus; phosphaalkene; phosphanylphosphonate; Wittig; Horner-Wittig; Horner-Wadsworth-Emmons; McMurry; Kemi; Chemistry;

   Sammanfattning : The formation of C=C bonds is of great importance for fundamental and industrial synthetic organic chemistry. There are many different methodologies for the construction of C=C bonds in the literature, but currently only the McMurry reaction allows the reductive coupling of two carbonyl compounds to form alkenes. LÄS MER

7. 5. Olefins from carbonyls : Development of new phosphorus-based cross-coupling reactions

   Författare :Nicolas Daniele D'Imperio; Sascha Ott; Carlos Romero-Nieto; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; olefins; carbonyl olefination; phosphaalkenes; stereoselective synthesis; Wittig; Horner-Wadsworth-Emmons; McMurry;

   Sammanfattning : Olefins, compounds containing C=C double bonds, are omnipresent in nature and serve as useful starting materials for various chemical modifications. Olefins are of crucial importance in Medicinal Chemistry and are also present in essential objects like dyes, polymers and plastics. LÄS MER