Sökning: "okadaic acid"
Visar resultat 1 - 5 av 14 avhandlingar innehållade orden okadaic acid.
1. Molecular targets for glucocorticoids in macrophages: cytosolic phospholipase A2 and cytokine formation
Sammanfattning : The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. LÄS MER
2. In vitro cellular models for neurotoxicity studies : neurons derived from P19 cells
Sammanfattning : Humans are exposed to a variety of chemicals including environmental pollutants, cosmetics, food preservatives and drugs. Some of these substances might be harmful to the human body. LÄS MER
3. Protein phosphorylation cascades regulating islet beta-cell insulin exocytosis through glucose sensing and drug signaling : with special focus on serine/threonine protein phosphates and hypoglycemic sulfonylureas
Sammanfattning : In human type 2 diabetes, loss of glucose-sensitive insulin secretion from the pancreatic �-cell is an early pathogenetic event. Initially, this may be compensated for by stimulating insulin secretion by sulfonylurea drugs. LÄS MER
4. Studies of nucleotide receptors-induced calcium response in glomerular mesangial cells and afferent arterioles
Sammanfattning : It is known that intracellular calcium concentration ([Ca2+]i) changes in rat glomerular mesangial cells (GMC) and rabbit afferent arterioles (AA) in response to extracellular nucleotides. We studied the nucleotide-induced calcium response in cultured GMC and AA. LÄS MER
5. TNFalpha expression in monocytes/macrophages
Sammanfattning : The recognition of microbes or microbial products by leukocytes is a key event in innate immunity. Binding of microbial products to cell surface receptors on phagocytes induce a response that includes the production of inflammatory mediators. One such mediator is the cytokine tumour necrosis factor alpha (TNF). LÄS MER