Sökning: "off-label"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet off-label.

1. 1. Drug treatment in children with focus on off-label drug use

   Författare :Elin Kimland; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Child; drug treatment; off-label; drug related problems; adverse drug reactions; drug labelling;

   Sammanfattning : There is a lack of paediatric documentation concerning efficacy and safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using different settings and design to evaluate pharmacological treatment in children, with focus on off-label drug use, is presented. LÄS MER

3. 2. Off-label drug treatment and related problems in children : a register-based investigation

   Författare :Elin Kimland; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Child; drug therapy; drug labelling; off-label; drug information services; adverse drug reactions; prescription drugs; drug related problems;

   Sammanfattning : Introduction: There is a lack of pediatric documentation concerning efficacy and safety of many drugs, which may contribute to off-label drug treatment and increase the risk for adverse drug reactions (ADRs). Aims: To; (I) analyse the frequency and characteristics of pediatric off-label prescribing; (II) investigate frequency of off-label drug prescribing in pediatric ADR reports; (III) analyse drug related problems, the extent of off-label drug treatment in pediatric questions to a Drug Information Centre (DIC) and pediatric literature information adding to the labelling of the drug in DIC answers. LÄS MER

4. 3. Off-label drug use, medication errors and adverse drug events : among Swedish pediatric inpatients

   Författare :Per Nydert; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: In pediatrics, treatment with drugs is an important and fully integrated part of everyday medical practice. However, authorized drugs specified to be used in children are often lacking which leads to off-label use, i.e. outside of approved product monographs. LÄS MER

5. 4. Effect of Drugs on Rabbit Retina

   Författare :Anna Cardiakidis Myers; Lund Oftalmologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug toxicity; electroretinography; histopathology; intravitreal injection; rifabutin; anti-VEGF; triamcinolone; benzyl alcohol; anti-TNF-alpha; adalimumab;

   Sammanfattning : The adverse effects of drugs in the eye are not easily detected, and the underlying pathogenesis not fully understood. The effects of four different kinds of drugs have been investigated in the rabbit eye, using electroretinography, ocular examination and histochemical methods. LÄS MER

7. 5. Computational modelling of blood flow in medical assist devices

   Författare :Francesco Fiusco; Lisa Prahl Wittberg; Lars Mikael Broman; Anders Dahlkild; David Ku; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; computational fluid dynamics; haemodynamics; platelet activation; thrombogenicity; haemolysis; extracorporeal membrane oxygenation; sensitivity; Teknisk mekanik; Engineering Mechanics;

   Sammanfattning : Extracorporeal membrane oxygenation (ECMO) is a life-saving support treat-ment in case of pulmonary and/or cardiac failure. An artificial extracorporealcircuit is used to offload the function of lungs and/or heart. LÄS MER