Sökning: "obesitas"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet obesitas.

1. 1. Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease

   Författare :Samer Al-Dury; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinska sjukdomar; Gastroenterologi och hepatologi; FXR; IBAT; Gallsyror; Obesitas; Gallstenar;

   Sammanfattning : Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic modality for a range of liver and metabolic diseases. LÄS MER

3. 2. Altered body composition in adults with complex congenital heart disease

   Författare :Karna Johansson; Camilla Sandberg; Bengt Johansson; Thomas Mooe; Mats Börjesson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adults with complex congenital heart disease; ACHD; body composition; skeletal muscle; lean mass; muscular strength; sarcopenia; bone; bone mass; bone mineral density; bone health; osteoporosis; fat; fat mass; obesity; Vuxna med medfödda hjärtfel; vuxna med komplexa medfödda hjärtfel; komplexa medfödda hjärtfel; kroppssammansättning; skelettmuskel; styrka; sarkopeni; ben; benmassa; bendensitet; osteoporos; fett; fettmassa; obesitas; kardiologi; Cardiology;

   Sammanfattning : Introduction: Thanks to achievements in paediatric heart surgery and medicine, the population of adults with surgically repaired or palliated congenital heart defects is growing. Many of these adults have reduced exercise capacity, weaker muscular strength and shorter height, all of which suggest an altered body composition. LÄS MER

4. 3. The relationship between overweight and depression in view of genes, environment and their joint influence

   Författare :Sofia H. Kanders; Cecilia Åslund; Kent W. Nilsson; Dan Larhammar; Nancy Pedersen; Uppsala universitet; []
   Nyckelord :depression; overweight; obesity; plasticity; pharmacogenetics; genetics; antidepressants; breastfeeding; bullying; depression; övervikt; obesitas; plasticitet; farmakogenetik; genetik; antidepressiva läkemedel; mobbning; amning; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Obesity and depression are known to often go hand in hand, but is this due to our genetic heritage, environmental factors or a combination thereof? With a neuroscientific approach, I have investigated the relationship between obesity and depression with the aim of bridging the different levels of research available in order to better understand this complex topic. Using data from a longitudinal cohort with adults, we analysed the genetic contribution to antidepressant response in Study I. LÄS MER

5. 4. On massive weight loss and body contour

   Författare :Jonas Ockell; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Excess skin; överskottshud; obesitas; obesity; bariatric surgery; bariatrisk kirurgi; brösthypertrofi; breast hypertrophy;

   Sammanfattning : Abstract Background/Aims: Bariatric surgery is an effective treatment for severe obesity. However, massive weight loss is associated with adverse effects, such as excess skin. LÄS MER

7. 5. Validation and application of objective measures of obesity and physical activity : studies in pregnant and non-pregnant adults and in infants

   Författare :Anna Gradmark; Paul W Franks; David Fields; Umeå universitet; []
   Nyckelord :physical activity; validation; body composition; abdominal adipose tissue; methods; accelerometer; pregnancy; insulin sensitivity; offspring;

   Sammanfattning : Background Excess adipose tissue and low physical activity are two major determinants for chronic diseases such as type 2 diabetes and cardiovascular disease.  Understanding these relationships requires accurate and precise measures of body composition and physical activity, and most existing observational studies lack such measures. LÄS MER