Sökning: "nucleus accumbens"

Visar resultat 21 - 25 av 66 avhandlingar innehållade orden nucleus accumbens.

  1. 21. Involvement of the Opioid System in High Alcohol Consumption : Environmental and Genetic Influences

    Författare :Karolina Ploj; Jörgen A Engel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Opioids; ethanol; stress; maternal separation; neonatal handling; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : It is well accepted that both inherent and environmental factors influence the pathogenesis of alcohol dependence. This thesis investigates the role of the opioid system in the initiation and maintenance of high ethanol intake. LÄS MER

  3. 22. On cholinergic mechanisms involved in ethanol reinforcement. A behavioral and neurochemical study in rodents

    Författare :Anna Larsson; Göteborgs universitet; []
    Nyckelord :Acetylcholine; Dopamine; Ethanol; Locomotor activity; Microdialysis; Nicotine; Nicotinic acetylcholine receptors; Rodents; Reward;

    Sammanfattning : Alcohol (ethanol) and smoking (nicotine) are commonly co-abused in human beings. Drugs of abuse interact with the brain mesolimbic dopamine system, an important part of the brain reward system. These dopaminergic neurons originate in the ventral tegmental area and project to e.g. LÄS MER

  4. 23. Experimental studies on the sources, pathways and targets for volume transmission in the rat brain

    Författare :Anders Jansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :volume transmission; extracellular space; monoamines; Dl D2 receptors; 5HT2A receptors; nitric oxide; interleukin-1ß; cholecystokinin; galanin;

    Sammanfattning : Volume transmission has been defined as the three-dimensional diffusion or convection of transmitters in the extracellular space (ECS) and cerebrospinal fluid (CSF) over a larger distance than the synaptic cleft. The regional localization of dopamine (DA) nerve terminals and dopamine Dl and D2 receptors in nucleus accumbens were studied in detail using double immuno-labelling. LÄS MER

  5. 24. Appetitive and consummatory ingestive behavior : role of taste, dopamine and NPY

    Författare :Fredrik Sederholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The present thesis has examined the role of taste, dopamine and neuropeptide Y (NPY) in the regulation of the two phases of ingestive behavior: appetitive (approaching and handling of food) and consummatory ingestive behavior (chewing and swallowing). Behavioral studies were performed in male and female rats. THE ROLE OF TASTE. LÄS MER

  7. 25. Predictors of Alcohol Misuse : Role of MAOA Genotype, Methylation, Transcription, and Negative and Positive Environmental factors

    Författare :Megha Bendre; Kent Nilsson; Erika Comasco; Ingrid Nylander; Mia Ericson; Uppsala universitet; []
    Nyckelord :Alcohol; AUD; MAOA; methylation; expression; early-life stress; maltreatment; parent–child relationship; gene–environment interactions.; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Alcohol misuse is a risk factor for alcohol use disorder (AUD). Gene-environment interactions contribute to the risk or resilience for AUD. A functional polymorphism in the promoter of the monoamine oxidase A gene (MAOA-uVNTR), in interaction with negative environment (Eneg), is associated with alcohol misuse and AUD. LÄS MER