Sökning: "nucleus accumbens"

Visar resultat 11 - 15 av 66 avhandlingar innehållade orden nucleus accumbens.

  1. 11. On natural and drug-induced reward : genetic, biochemical and behavioral comparisons

    Författare :Martin Werme; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :VTA; nucleus accumbens; wheel running; exercise; drugs of abuse; addiction; compulsive; deltaFosB; Nurr1; Dynorphin;

    Sammanfattning : Work in this thesis compares natural and drug- induced reward at genetic, biochemical and behavioral levels with the objective to obtain information about key mechanisms underlying reward and addiction, and improve the understanding of compulsive elements that characterize addiction. Surveys among committed human runners have described running as addictive. LÄS MER

  3. 12. The phencyclidine model of schizophrenia : dysregulation of brain dopamine systems induced by NMDA receptor antagonists

    Författare :Jan M Mathé; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :phencyclidine; MK-801; CNQX; prazosin; tetrodotoxin; dopamine; neurotensin; ventral tegmental area; nucleus accumbens; medial prefrontal cortex;

    Sammanfattning : Non-competitive NMDA receptor antagonists, such as phencyclidine (PCP) and dizocilpine (MK-801) can even acutely induce a drug induced psychotic state which closely resembles schizophrenia. The midbrain dopamine (DA) neurons, which originate in the ventral tegmental area (VTA), are involved in motivational, attentional and cognitive processes, and have also been profoundly implicated in schizophrenia. LÄS MER

  4. 13. Novel pharmacological treatment alternatives for nicotine dependence

    Författare :Nina Lindblom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nicotine; dependence; withdrawal; reinstatement; smoking; active immunisation; immunoconjugate; vaccine; dopamine stabiliser; - -DS121; dopamine; nucleus accumbens; intra cranial selfstimulation;

    Sammanfattning : Smoking has been identified as the single largest preventable cause of morbidity and premature death in the developed world. Despite the well known health risks associated with smoking the number of smokers are still rising globally. LÄS MER

  5. 14. Neurobiological basis of the nicotine withdrawal reaction : an experimental analysis

    Författare :Bengt E Hildebrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :rat; nicotine; nicotine withdrawal; behavior; locomotor activity; microdialysis; intracerebral injections; mesolimbocortical; dopamine; ventral tegmental area; nucleus accumbens; amygdala; immediate-early genes; c-fos;

    Sammanfattning : The mesolimbocortical dopamine (DA) system is pivotal for the mediation of the reinforcing effects of many dependence-producing drugs. It consists of cell bodies in the ventral tegmental area (VTA) that project to e.g. the nucleus accumbens (NAC), the central nucleus of amygdala (CNA) and the medial prefrontal cortex. LÄS MER

  7. 15. Perinatal asphyxia in the rat : a morphological and functional analysis of the dopamine systems and dopamine-mediated behaviours in a novel experimental model

    Författare :Yong Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rat; Perinatal asphyxia; Dopamine; Noradrenaline; Dopamine receptors; Substantia nigra; Ventral tegmental area; Striatum; Accumbens nucleus; Locomotor activity; Attention disorders; bFGF; Fos; pH; pyruvate; lactate; glutamate; aspartate.;

    Sammanfattning : Asphyxia during labour in the human being is one of the important paediatric complications which can lead to various degree of injuries in the central nervous system. No efficient therapy is available at present. LÄS MER