Sökning: "nucleotide oligomerization domain protein"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden nucleotide oligomerization domain protein.

1. 1. NA transmembrane domain : Amphiphilic drift to accommodate two functions

   Författare :Johan Nordholm; Robert Daniels; Ervin Fodor; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; influenza; IAV; neuraminidase; NA; transmembrane domain; TMD; secretory protein; ER-targeting sequence; ER-targeting sequence coding region; protein regulation; NS1; GALLEX; Biochemistry; biokemi;

   Sammanfattning : Neuraminidase (NA) is one of two major antigens on the surface of influenza A viruses. It is comprised of a single N-terminal transmembrane domain (TMD), a stalk domain, and a C-terminal enzymatic head domain that cleaves sialic acid, most notably to release new particles from the host cell surface. LÄS MER

3. 2. Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei

   Författare :Munender Vodnala; Anders Hofer; Arne Holmgren; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Trypanosoma brucei; adenosine kinase; thymidine kinase; methylthioadenosine phosphorylase; mouser ribonucleotide reductase; E. coli ribonucleotide reductase; RNR; Ara-A; F-Ara-A; dNTP; NTP; doexynucleotide metabolism; nucleosides; nucleoside kinases; allosteric regulation; biologisk kemi; biological chemistry;

   Sammanfattning : Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs.T. LÄS MER

4. 3. Innate immunity atherosclerosis : signaling pattern recognition receptors and an antimicrobial peptide

   Författare :Kristina Edfeldt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Atherosclerosis; innate immunity; inflammation; Toll-like receptor; nucleotide oligomerization domain protein; antimicrobial peptide;

   Sammanfattning : Atherosclerosis, a disease characterized by fibroinflammatory lipid lesions in the arterial wall, is the leading cause of mortality in the Western world. For decades research has been aimed at dissecting the pathogenesis of this multifactorial disease. LÄS MER

5. 4. DNA precursor biosynthesis-allosteric regulation and medical applications

   Författare :Reza Rofougaran; Anders Hofer; Thomas Borén; Staffan Eriksson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; DNA biosynthesis; ribonucleotide reductase; allosteric regulation; Trypanosoma brucei; adenosine kinase; nucleoside analogs; mitochondrial DNA; TWINKLE; Biokemi; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : Ribonucleotide reductase (RNR) is a key enzyme for de novo dNTP biosynthesis. We have studied nucleotide-dependent oligomerization of the allosterically regulated mammalian RNR using a mass spectrometry–related technique called Gas-phase Electrophoretic Mobility Macromolecule Analysis (GEMMA). LÄS MER

7. 5. Pattern-recognition receptors in airway inflammation

   Författare :Anna-Karin Ekman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Airway inflammation is a defining feature of allergic rhinitis and asthma. Bacterial and viral infections are known to cause exacerbations of both diseases, but knowledge about the mechanisms involved is limited. LÄS MER