Sökning: "nucleotide analogues"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden nucleotide analogues.

1. 1. Studies on Nucleotide Analogues Containing P-S-C Bond

   Författare :Renáta Híresová; Stockholms universitet; []
   Nyckelord :;

   Sammanfattning : .... LÄS MER

3. 2. Structural Studies of Human 5'-Nucleotidases

   Författare :Karin Walldén; Pär Nordlund; Norbert Sträter; Stockholms universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Nucleotidases; nucleotide; nucleoside; nucleoside analogue; Structural biochemistry; Strukturbiokemi; biokemi; Biochemistry;

   Sammanfattning : 5’-Nucleotidases (5’NTs) are catabolic enzymes of the nucleotide metabolism. They catalyze dephosphorylation of deoxyribo- and ribonucleoside monophosphates and constitute an important control point in the regulation of intracellular nucleotide pools for the maintenance of correct DNA and RNA synthesis. LÄS MER

4. 3. Studies on nucleoside H-phosphonoselenoate chemistry and chalcogen exchange reaction between P(V) and P(III) compounds

   Författare :Martin Kullberg; Jacek Stawinski; Wojciech Markiewicz; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phosphorus chemistry; H-phosphonate; H-phosphonoselenoate; nucleotide analogues; selenization; selenium transfer; phosphoroselenoate; Organic chemistry; Organisk kemi;

   Sammanfattning : In this thesis, the chemistry of compounds containing P-Se bonds has been studied. As a new addition to this class of compounds, H-phosphonoselenoate monoesters, have been introduced and two synthetic pathways for their preparation have been developed. LÄS MER

5. 4. Towards synthesis of biologically important phosphate analogues : exploring H-phosphonate and C-phosphonate chemistry

   Författare :Annika Kers; Robert Letsinger; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

   Sammanfattning : This thesis is based on studies directed towards the development of methods for the preparation of phosphorus containing natural products, with the focus on C-phosphonate nucleic acid analogues.Mechanistic studies concerning formation of the phosphorus-carbon bond resulted in development of two efficient protocols for the synthesis of C-phosphonates from the corresponding H-phosphonate derivatives. LÄS MER

7. 5. Studies on the synthesis of nucleotide analogues containing P-F and P-Se bonds

   Författare :Martin Bollmark; Janusz Rachon; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

   Sammanfattning : In the present work, new synthetic approaches to the synthesis of nucleoside phosphorofluoridate and phosphorofluoridothioate diesters have been developed. These procedures involve either oxidative transformation of the corresponding H-phosphonate or H-phosphonothioate diesters in the presence of fluoride anion or iodine-promoted desulfurization of phosphorothioate or phosphorodithioate diesters in the presence of fluoride anion. LÄS MER