Sökning: "nucleic acid sequence"

Visar resultat 1 - 5 av 58 avhandlingar innehållade orden nucleic acid sequence.

  1. 1. Deciphering sequence data : A multivariate approach

    Författare :Maria Sandberg Hiltunen; Michael Sjöström; Svante Wold; Lars Ståhle; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Principal properties; amino acids; nucleotides; tRNA; DNA; multivariate data analysis; sequence analysis; QSAR; quantitative sequence activity relationships;

    Sammanfattning : In this thesis, attention has been focused on the quantitative description of nucleic acids, proteins and peptides. The strategy was to use multivariate chemometrical methods for improving the understanding of the complex structural codes of these kinds of biological molecules. LÄS MER

  3. 2. Molecular Tools for Nucleic Acid Analysis

    Författare :Deirdre O'Meara; KTH; []
    Nyckelord :nucleic acid capture; modular probes; biosensor; bio-magnetic separation; hepatitis C; sequencing; pyrosequencing; mutation detection; HIV-1; drug resistance; SNP; allele-specific extension; apyrase; genotyping.;

    Sammanfattning : Nucleic acid technology has assumed an essential role invarious areas ofin vitrodiagnostics ranging from infectious diseasediagnosis to human genetics. An important requirement of suchmolecular methods is that they achieve high sensitivity andspecificity with a fast turnaround time in a cost-effectivemanner. LÄS MER

  4. 3. Patentability of nucleic acid related inventions in Europe and in the USA

    Författare :Kristina Runeberg; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; patentability; expressed sequence tags; United States Patent and Trademark Office; European Patent Office; EPO; nucleic acid; USPTO; ESTs; patent; DNA;

    Sammanfattning : .... LÄS MER

  5. 4. Thermodynamics of Peptide Nucleic Acid Interactions with DNA

    Författare :Tommi Ratilainen; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; thermodynamics; enthalpy-entropy compensation; ionic strength; nucleic acids; fluorescence energy transfer; PNA; calorimetry; sequence-specific binding;

    Sammanfattning : Peptide Nucleic Acid (PNA) is a DNA mimic with the natural nucleobases attached to a charge-neutral pseudopeptide backbone. It has remarkably strong and sequence-specific binding affinity to natural nucleic acids (DNA and RNA), mainly attributed to the lack of charge in the PNA backbone. LÄS MER

  7. 5. Nucleic acid based therapeutic approaches

    Författare :Joacim Elmén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nucleic acid therapy comprises several approaches based on nucleic acid as the active therapeutic component to treat human disease. Antisense and short interfering RNA (siRNA) are two gene-silencing techniques in this category. Based on nucleic acid sequence recognition both techniques inhibit gene expression. LÄS MER