Sökning: "nuclear-mitochondrial interaction"

Hittade 2 avhandlingar innehållade orden nuclear-mitochondrial interaction.

1. 1. Mitochondrial and chromosomal genomics in type 2 diabetes

   Författare :Avinash Abhyankar; Genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adaptive evolution; nuclear-mitochondrial interaction; linkage analysis; QTL; phylogenetic analysis; congenic; type 2 diabetes; GK rat;

   Sammanfattning : Understanding the mechanisms of complex polygenic diseases like type 2 diabetes (T2D) is as complex as their nature. Cellular processes involved in glucose homeostasis need high and reliable energy supply. Mitochondria are the major energy producers in mammalian cells. LÄS MER

3. 2. DNA damage-induced cell death : the role of caspase-2

   Författare :Helin Vakifahmetoglu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Apoptosis; caspase-2; DNA damage; mitotic catastrophe; p53;

   Sammanfattning : Activation of a family of cysteine proteases, called caspases, is an important event during apoptosis. In comparison to other caspases, less is known about regulatory functions of caspase-2. Previous studies from our group established caspase-2 as an essential apical regulator of apoptosis triggered by DNA damage. LÄS MER