Sökning: "nuclear transcription factors"

Visar resultat 1 - 5 av 215 avhandlingar innehållade orden nuclear transcription factors.

1. 1. From Single Gene to Whole Genome Studies of Human Transcription Regulation

   Författare :Alvaro Rada-Iglesias; Claes Wadelius; Henk Stunnenberg; Uppsala universitet; []
   Nyckelord :Genetics; transcription; ChIP-chip; genome-wide; transcription factors; in vivo; Genetik;

   Sammanfattning : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. LÄS MER

3. 2. Genetic and Genomic Analysis of Transcriptional Regulation in Human Cells

   Författare :Mehdi Motallebipour; Claes Wadelius; Gunnar Westin; Dirk Schübeler; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcription; ChIP-chip; ChIP-seq; genome-wide; transcription factors; microsatellite; epigenetic; Medical genetics; Medicinsk genetik;

   Sammanfattning : There are around 20.000 genes in the human genome all of which could potentially be expressed. However, it is obvious that not all of them can be active at the same time. Thus, there is a need for coordination achieved through the regulation of transcription. LÄS MER

4. 3. Inflammatory transcription factors in atherosclerosis

   Författare :Wolfgang Dichtl; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular system; Kardiovaskulära systemet;

   Sammanfattning : Transcription factors such as nuclear factor-kB (NF-kB), activator protein-1 (AP-1) and peroxisome proliferator-activated receptors (PPARs) may play important roles in atherogenesis, by regulating chronic subclinical vascular inflammation. In the first study, we showed that VLDL activates the proinflammatory transcription factor NF-kB in endothelial cells both in vitro and in vivo. LÄS MER

5. 4. Regulation of Human Mitochondrial DNA Replication and Transcription

   Författare :Majda Mehmedovic; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mtDNA; replication; transcription; TFAM;

   Sammanfattning : Mitochondria are organelles in eukaryotic cells, which through oxidative phosphorylation (OXPHOS) produce most of the ATP used to drive cellular processes. The organelle contains its own genetic material, mitochondrial DNA (mtDNA), which encodes 13 key components of the OXPHOS machinery. LÄS MER

7. 5. Viral Strategies to Regulate Transcription and Pre-mRNA Splicing

   Författare :Shaoan Fan; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Adenovirus E1B-55kDa; E4-ORF4; E4-ORF6 proteins; L1 mRNA; Polyoma virus small T antigen; regulation; transcription; splicing; PP2A; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

   Sammanfattning : A typical DNA virus encodes for a few key regulatory proteins that modify the host cell biosynthetic machinery to achieve a selective viral gene statement. One such example is illustrated by the adenovirus E4-ORF4 protein, which form an enzymatically active complex with the serine and threonine-specific protein phosphatase 2A (PP2A). LÄS MER