Sökning: "nuclear lamina"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden nuclear lamina.

1. 16. Metalloproteinases in development and disease

   Författare :Zhongjun Zhou; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Metalloproteinases are Zn-dependent proteases composed of five superfamilies. One important subfamily is the matrix metalloproteinases (MMPs) that process various components of the extracellular matrix (ECM) and non-ECM proteins. LÄS MER

3. 17. Development of a mouse model for Hutchinson-Gilford progeria syndrome reveal defects in adult stem cell maintenance

   Författare :Ylva Rosengardten; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Hutchinson-Gilford progeria syndrome (HGPS) is a very rare genetic disease that presents some features of accelerated aging. Children with the disease are born appearing healthy but start to develop signs of the disease within their first years of life. LÄS MER

4. 18. Defining the role of CAAX protein proteolysis and methylation in the pathogenesis and treatment of progeria

   Författare :Xue Chen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Hutchinson-Gilford progeria syndrome (HGPS) is a rare childhood disease characterized by failure to thrive, bone abnormalities, hair loss, and a shortened life span due to cardiovascular disease, and nuclear shape abnormalities in cultured cells. HGPS is caused by de-novo mutations in LMNA, the gene encoding prelamin A. LÄS MER

5. 19. Novel FISH methods to unveil genome architecture

   Författare :Ana Mota; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The genome consists of incredibly long DNA strands that encode all the vital information for the cell to function. The DNA inclusion in the very tight nuclear space and, simultaneously, the establishment of a hierarchical organization of the chromatin that favors transcription of certain genes over others, sparked a long-lasting quest to understand the design principles that govern genome architecture. LÄS MER

7. 20. Epithelial stem cells in Hutchinson-Gilford progeria syndrome

   Författare :Tomás McKenna; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) are two rare genetic disorders that affect children. Complications from cardiovascular disease, including atherosclerosis, are the most common cause of death in HGPS, which occurs at around 13 years of age. LÄS MER