Sökning: "nuclear factor-kappa B"

Visar resultat 1 - 5 av 33 avhandlingar innehållade orden nuclear factor-kappa B.

1. 1. INITIATION OF EXPERIMENTAL ACUTE PANCREATITIS AND MODULATION OF INFLAMMATORY RESPONSE

   Författare :Jakob B Axelsson; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nuclear factor kappa B; neutrophils; monocytes; acute pancreatitis; ductal cells; active site-inhibited factor seven; heparan sulfate; lipopolysaccharide; innate immune response;

   Sammanfattning : Heparan sulfate (HS), a substance common in the extracellular matrix on epithelial cells is present in the pancreas, lining the duct lumen. During pathological conditions, we propose that it can be shed from the ECM and bind to receptors on the cell surface, thus triggering an inflammatory response, which if excessive can cause acute pancreatitis (AP). LÄS MER

3. 2. Crosstalk between Inflammation and Coagulation in Acute Pancreatitis - Experimental and Clinical Studies

   Författare :Ellen Andersson; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; acute pancreatitis; active site inactivated factor VII; bleeding; coagulation; factor VII; FVIIai; hemorrhagic complications; hemorrhage; interleukin-6; MIP-2; nuclear factor kappa B; tissue factor;

   Sammanfattning : In various inflammatory conditions a close interplay between inflammation and coagulation is known to exist, where coagulation factor VII (FVII) and tissue factor (TF) are considered to be pivotal players. In this thesis the crosstalk between inflammation and coagulation in acute pancreatitis (AP) has been investigated. LÄS MER

4. 3. The Role of Cyclooxygenase-2 in Models of Epilepsy and Traumatic Brain Injury : Effects of Selective Cyclooxygenase-2 Inhibitors

   Författare :Tina Kunz; Tadeusz Wieloch; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Controlled cortical contusion injury; fluid percussion injury; limbic seizures; nuclear factor-kappa B; prostaglandin metabolism; TUNEL staining; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

   Sammanfattning : Cyclooxygenase-2 (COX-2) catalyses prostaglandin synthesis from arachidonic acid during inflammation. COX-2 is expressed in the normal brain and is induced in neurological disorders. There is evidence that COX-2 is involved in secondary events leading to cell death in the brain. LÄS MER

5. 4. Role of environmental toxins in chronic experimental arthrithis - in search for anti-inflammatory pathways of ethanol and nicotine

   Författare :Sofia Silfverswärd Lindblad; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; collagen-induced arthritis; ethanol; testosterone; nuclear factor kappa B; smoking; nicotine; NMDA; regulatory T cells;

   Sammanfattning : Rheumatoid arthritis (RA) is a common systemic autoimmune disorder and a debilitating disease affecting 1% of the world population. The etiology of RA is an unresolved issue. Environmental factors such as alcohol intake and cigarette smoke have been described as contributing to the pathogenesis of RA. LÄS MER

7. 5. Insights into the processes preceding the onset of rheumatoid arthritis

   Författare :Linda Johansson; Solbritt Rantapää Dahlqvist; Mikael Brink; Felipe Andrade; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; pre-symptomatic individuals; autoantibodies; anti-citrullinated protein peptides antibodies; Epstein-barr virus; neutrophil extracellular traps; periodontitis; Porphyromonas gingivalis; receptor activator of nuclear factor kappa-B ligand; reumatologi; rheumatology;

   Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by the production of anti-citrullinated protein antibodies (ACPA) in the majority of all patients and a persistent inflammation in the synovial tissue leading to joint destruction. The aetiology of RA remains to a large extent unknown but is believed to be a complex interplay between genetic, environmental and stochastic factors. LÄS MER