Sökning: "nuclear factor 1"

Visar resultat 1 - 5 av 315 avhandlingar innehållade orden nuclear factor 1.

1. 1. Macrophage Activation and AP-1 in Atherosclerosis

   Författare :Maria Stollenwerk; Kardiovaskulär forskning - immunitet och ateroskleros; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Proteins; enzymology; Proteiner; enzymologi; Cardiovascular system; carotid plaque; interleukin-1b; caspase-1.; very low-density lipoprotein; fatty acids; activator protein-1; inflammation; Atherosclerosis; nuclear factor-kB; macrophages; tumor necrosis factor;

   Sammanfattning : High levels of very low density lipoprotein (VLDL) and intermediate density lipoprotein (IDL) have been identified as independent risk factors for coronary heart disease. Hypertriglyceridemia is generally associated with an increased expression of inflammatory makers and inflammation is thought to contribute to atherosclerosis and its complications. LÄS MER

3. 2. Hypoxia inducible factor 1 alpha : dependent and independent regulation of hematopoietic stem cells and leukemia

   Författare :Camilla Halvarsson; Jan-Ingvar Jönsson; Mikael Sigvardsson; Kamil Kranc; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : This thesis has studied the role of low oxygen levels, or hypoxia, in hematopoietic stem cells (HSCs) and how, at the molecular level, it regulates stem cell maintenance and protects against oxidative stress induced by reactive oxygen species (ROS). HSCs reside within the bone marrow in specific niches created by a unique vascularized environment, which is suggested to be hypoxic and crucial for HSCs by maintaining a quiescent state of cell cycle and by redirecting metabolism away from the mitochondria to glycolysis. LÄS MER

4. 3. Studies on nuclear factor 1 binding to nucleosomal DNA

   Författare :Patrik Blomquist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :nuclear factor 1; nucleosome; glucocorticoid receptor; triplex DNA; the SWISNF complex; A-tracts; MMTV LTR;

   Sammanfattning : The organisation of DNA into chromatin will influence on transcriptional regulation. The first event in transcriptional activation is the binding of transcription factors to specific binding sites in the regulatory regions of the gene. LÄS MER

5. 4. The MEN 1 Pancreas : Tumor Development and Haploinsufficiency

   Författare :Margareta Halin Lejonklou; Britt Skogseid; Peter Stålberg; Andreea Barbu; Gerard Doherty; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEN 1; PNET; tumor development; haploinsufficiency; survivin; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

   Sammanfattning : Multiple Endocrine Neoplasia Type I Syndrome (MEN 1) is a monogenic autosomal dominantly inherited cancer syndrome caused by a heterozygous loss of the MEN1 gene, predisposing for endocrine cell proliferation and tumor formation. MEN 1 carriers classically develop tumors in endocrine organs; the parathyroids, the endocrine pancreas, and the pituitary. LÄS MER

7. 5. MRI assessment of haemophilic arthropathy

   Författare :Björn Lundin; Lund Diagnostisk radiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radiologi; tomografi; medicinsk instrumentering; medical instrumentation; tomography; radiology; Clinical physics; Medicin människa och djur ; Medicine human and vertebrates ; Arthropathy; Factor VIII; Factor IX; MRI; Haemophilia; Klinisk fysiologi;

   Sammanfattning : Haemophilia is a recessive genetic bleeding disorder in which coagulation time is prolonged due to the absence or malfunction of either of the serum proteins Factor VIII or IX. Joint destruction following repeated haemarthroses is the main cause of morbidity in haemophiliacs, and such arthropathy can be prevented or postponed by implementing prophylactic therapy with factor concentrate at an early age. LÄS MER