Sökning: "normal tissue complication probability"

Visar resultat 6 - 10 av 12 avhandlingar innehållade orden normal tissue complication probability.

1. 6. Comparative treatment planning in external radiotherapy of malignant tumours : Potential gains using protons

   Författare :Ulf Isacsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Breast cancer; comparative treatment; Ewing sarcoma; oesophageal cancer; protontherapy; radiotherapy; rectal cancer; treatment planning algorithms; Onkologi; Oncology; Onkologi; Oncology; onkologi;

   Sammanfattning : It is well known that protons have physical characteristics superior to conventional radiation qualities in external beam radiotherapy. The primary aim of this work is to determine if the physical advantages also may lead to clinical advantages. LÄS MER

3. 7. Biological optimization of angle of incidence and intensity modulation in breast and cervix cancer radiation therapy

   Författare :Brigida Costa Ferreira; Anders Brahme; Roger Svensson; Ion Christian Chiricuta; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biological treatment planning; angle of incidence optimization; intensity modulation; breast and cervix cancer; Radiation biology; Strålningsbiologi;

   Sammanfattning : Biological treatment optimization aim at improving radiation therapy by accounting for the radiobiological tumour and normal tissues response properties when optimizing the dose delivery. Generally traditional methods, using only dosimetrical measures, disregard the nonlinear radiation response of different tumours and normal tissues. LÄS MER

4. 8. Relative biological effectiveness in proton therapy: accounting for variability and uncertainties

   Författare :Jakob Ödén; Iuliana Toma-Dasu; Kjell Eriksson; Radhe Mohan; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proton therapy; relative biological effectiveness; linear energy transfer; proton track-end optimisation; radiation-induced toxicity; Medical Radiation Physics; medicinsk strålningsfysik;

   Sammanfattning : Radiation therapy is widely used for treatments of malignant diseases. The search for the optimal radiation treatment approach for a specific case is a complex task, ultimately seeking to maximise the tumour control probability (TCP) while minimising the normal tissue complication probability (NTCP). LÄS MER

5. 9. Comparative Treatment Planning in Radiotherapy and Clinical Impact of Proton Relative Biological Effectiveness

   Författare :Jonas Johansson; Bengt Glimelius; Anders Montelius; Tony Lomax; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Radiotherapy; Comparative studies; Breast cancer; hypopharyngeal cancer; rectal cancer; Proton RBE; Onkologi; Oncology; Onkologi;

   Sammanfattning : The development of new irradiation techniques is presently a very active field of research with increased availability of more sophisticated modalities such as intensity modulated photons (IMRT), protons and light ions. The primary aim of this work is to evaluate if the dose-distributions using IMRT and protons contribute to clinical advantages. LÄS MER

7. 10. Nasopharyngeal carcinoma: past, present and future directions

   Författare :Zahra Taheri-Kadkhoda; Göteborgs universitet; []
   Nyckelord :Nasopharyngeal carcinoma; radiotherapy; side effects; 3DCRT; Intracavitary brachytherapy; IMRT; IMPT; LMP1; EGFR.; radiotherapy; side effects; 3DCRT; Intracavitary brachytherapy; IMRT; IMPT; LMP1; EGFR;

   Sammanfattning : Nasopharyngeal carcinoma (NPC) is a rare disease in Sweden. The purpose of this thesis was to investigate the clinicopathological manifestations of the disease and its treatment outcomes in a cohort of Swedish NPC patients to identify key features for future improvements in patient care. LÄS MER