Sökning: "nonobese diabetic mouse"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden nonobese diabetic mouse.

  1. 1. The genetic basis of T and B cell contribution to autoimmune diabetes in NOD mice

    Författare :Vinícius Motta; Dan Holmberg; Linda Wicker; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 Diabetes; NOD mouse; CTLA-4; superantigen; T cells; Idd; marginal zone B cells; embryo aggregation chimera; negative selection; Immunogenetics; Immungenetik;

    Sammanfattning : The nonobese diabetic mouse (NOD) is an excellent animal model to study type 1 diabetes. As with some humans, disease in the NOD mouse is effected by a combination of genetic and environmental factors. At least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified so far, both in humans and in the NOD mouse. LÄS MER

  3. 2. Interferons in antiviral defense and autoimmunity : focus on type 1 diabetes

    Författare :Monica Hultcrantz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 1 diabetes; interferons; islets of Langerhans; Coxsackievirus; nonobese diabetic mouse;

    Sammanfattning : Type 1 diabetes (T1D) is a disease characterized by the loss of insulin producing beta-cells in the pancreatic islets of Langerhans. Interferons (IFNs), produced by immune cells and infected parenchymal cells, may be protective or damaging in the pathogenesis of T1D. LÄS MER

  4. 3. B cell repertoire development in normal physiology and autoimmune disease

    Författare :Åsa Andersson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cell repertoire; connectivity; natural antibodies; non-obese diabetic NOD ; Ig therapy; Vh7183 gene family;

    Sammanfattning : The B cell repertoire in the neonatal immune system (IS) is characterised by reactivity towards self-components, including other immunoglobulin (Ig) V-regions. These properties have been suggested to be a requirement for the development of a normal immune system. LÄS MER

  5. 4. Antigen presenting cells in autoimmune diabetes: phenotype, function and modulation by Linomide

    Författare :Eva Dahlén; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; Endocrinology; Linomide; costimulation; TNF-a; dendritic cells; Diabetes; macrophages; diabetology; Endokrinologi; sekretion; diabetologi; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : The aim of this thesis was to better understand the role of antigen presenting cells (APC) in the development of diabetes in the nonobese diabetic (NOD) mouse. We have shown that DC and Mphi that infiltrate the islets of Langerhans produce tumour necrosis factor-a (TNF-a), a cytokine known to contribute to the pathogenesis in the early stages of diabetes development. LÄS MER

  7. 5. Type 1 diabetes : the autoimmune process and islet transplantation

    Författare :Stella Jacobson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective loss of the insulin-producing β-cells residing in the islets of Langerhans in the pancreas. Cytokines are involved in diabetes development in the nonobese diabetic (NOD) mouse model. LÄS MER