Sökning: "nodular sclerosis"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden nodular sclerosis.

  1. 1. Clinical and immunopathological studies in Hodgkin's disease with special reference to prognosis

    Författare :Ulla Axdorph; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hodgkin's disease (HD) and non-Hodgkin lymphoma (NHL) have certain features in common, but also distinct clinical and pathological differences. Thus, HD has many features of both an infectious (fever, leukocytosis, eosinophilia, night sweats, lymphadenopathy, splenomegaly) and a malignant process with few tumour cells, T-cell accumulation and sclerosis. LÄS MER

  3. 2. Hodgkin Lymphoma – an Interplay Between Tumour Cell and Microenvironment

    Författare :Ingrid Glimelius; Gunilla Enblad; Daniel Molin; Rose-Marie Amini; Marie Fischer; Volker Diehl; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN; Oncology; onkologi;

    Sammanfattning : Hodgkin lymphoma (HL) is a malignant disorder characterised by few tumour cells surrounded by a massive infiltrate of inflammatory cells, fibrosis, and microvessels. Therefore, it is a good model in which to study the interplay between tumour cells and the microenvironment. LÄS MER

  4. 3. Bystander Cells and Prognosis in Hodgkin Lymphoma

    Författare :Daniel Molin; Stephen J. Proctor; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Hodgkin Lymphoma; Bystander cells; Eosinophilic granulocytes; Eosinophil cationic protein ECP ; Mast cells; Prognosis; Early and Intermediate stage; Onkologi; Hodgkin lymfom; eosinofila granulocyter; ECP; mast celler; prognos; tidiga och intermediära stadier; Oncology; Onkologi; Oncology; onkologi;

    Sammanfattning : Hodgkin lymphoma (HL) is characterised histologically by a minority of malignant Hodgkin and Reed-Sternberg (HRS) cells surrounded by benign cells, and clinically by a relatively good prognosis. The treatment, however, leads to a risk of serious side effects. LÄS MER

  5. 4. Eosinophil Cationic Protein : Expression Levels and Polymorphisms

    Författare :Jonas Byström; Helene Rosenberg; Uppsala universitet; []
    Nyckelord :Medical sciences; Eosinophils; Neutrophils; Monocytes; Macrophages; mRNA; eosinophil cationic protein; DNA; polymorphism; Hodgkin Lymphoma; asthma; allergy; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Clinical Chemistry; klinisk kemi;

    Sammanfattning : The eosinophil cationic protein (ECP) is usually associated with the eosinophil granulocyte. In this thesis the presence and production of this protein has been studied in two other cells. The circulating monocyte was found to contain ECP mRNA and small amounts of ECP, one thousand times less than that found in the eosinophil. LÄS MER

  7. 5. Transcriptome based analysis of Hodgkin lymphoma : insights into the microenvironment

    Författare :Anna Birgersdotter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hodgkin lymphoma; Epstein-Barr virus; gene expression; tissue culture; cell-line models;

    Sammanfattning : This thesis is focused on the analysis of Hodgkin lymphoma (HL), in particular the complex interaction between the malignant cells and the abnormally behaving bystander cells, and this complexity of the inflammatory infiltrate in HL constantly challenge scientists. The common thread in this thesis is the usage of gene expression profiling of whole tumour tissues, laser-captured Hodgkin Reed Sternberg (H-RS) cells and of cell-lines. LÄS MER