Sökning: "nitric oxide synthase"

Visar resultat 21 - 25 av 189 avhandlingar innehållade orden nitric oxide synthase.

  1. 21. Helicobacter pylori interference with the L-arginine/NO pathway in the upper gut

    Författare :Charlotte Von Bothmer; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acid; bicarbonate; duodenal ulcer; Helicobacter pylori; host defence; mucosa; nitric oxide; nitric oxide synthase;

    Sammanfattning : Helicobacter pylori causes chronic gastritis and sometimes peptic ulcers but the pathogenesis is not fully understood. H. pylori-infected individuals with duodenal ulcer have an impaired duodenal mucosal bicarbonate secretion (DMBS) in response to acid. NO is an important signalling molecule in the body. LÄS MER

  3. 22. Nitric oxide (NO) and carbon monoxide (CO): A novel class of messenger molecules regulating insulin and glucagon secretion

    Författare :Ragnar Henningsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; carbon monoxide CO ; nitric oxide NO ; Nitric oxide synthase NOS ; Insulin and glucagon secretion; cyclic nucleotides; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi; Heme oxygenase HO ;

    Sammanfattning : During the last decade it has been shown that nitric oxide (NO) and carbon monoxide (CO) are produced in our own body, and that they constitute a novel class of messenger molecules. In 1992 a constitutive NO-producing NO-synthase (cNOS) was found in the islets of Langerhans, and in 1997 we could show for the first time that the islets also contained a CO-producing constitutive heme oxygenase (HO-2). LÄS MER

  4. 23. Role of Inducible Nitric Oxide Synthase and Melatonin in Regulation of β-cell Sensitivity to Cytokines

    Författare :Annika K. Andersson; Stellan Sandler; Nils Welsh; Décio L. Eizirik; Nils Billestrup; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cell; Cyclooxygenase; Cytokine; Diabetes; IFN-γ; IL-1β; iNOS; Insulin; Melatonin; Nitric oxide; Pancreatic islets; Phospholipase D; Prostaglandin E2; Streptozotocin; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : The mechanisms of β-cell destruction leading to type 1 diabetes are complex and not yet fully understood, but infiltration of the islets of Langerhans by autoreactive immune cells is believed to be important. Activated macrophages and T-cells may then secrete cytokines and free radicals, which could selectively damage the β-cells. LÄS MER

  5. 24. Inducible nitric oxide synthase : in vascular smooth muscle cells

    Författare :Zhong-qun Yan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :nitric oxide; nitric oxide synthase; vascular smooth muscle cells; transcriptional regulation; NF-[kappa]B; I[kappa]B; pathophysiological role;

    Sammanfattning : Besides the constitutively expressed nitric oxide synthase (NOS) in endothelial cells, vascular smooth muscle cells (SMC) have the potential to express the inducible isoform of NOS (iNOS). Given the important effects of nitric oxide and the high output of this enzyme, expression of iNOS in SMC and its pathophysiological significance were investigated in the present study. LÄS MER

  7. 25. Electron and Proton Transfer in Nitric Oxide Reductase : NO Binding, NO Reduction and no Pumping

    Författare :Peter Lachmann; Pia Ädelroth; Peter Brzezinski; Fahmi Himo; Stockholms universitet; []
    Nyckelord :Flow-Flash; Nitric Oxide Reductase; Heme Copper Oxidase;

    Sammanfattning : Nitric oxide reductase (NOR) from Paracoccus denitrificans catalyzes the two electronreduction of NO to N2O (2NO + 2H+ + 2e- → N2O + H2O) as part of the process ofdenitrification, the step-wise reduction of nitrate to dinitogen. The NOR-catalyzedreaction is central in the nitrogen cycle, since in this step the N=N double bond isformed. LÄS MER