Sökning: "niklas uppsala biologi"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden niklas uppsala biologi.
1. Studies of Budding Yeast Transcription Factors Acting Downstream of Nutrient Signaling Pathways
Sammanfattning : Being able to respond to extracellular cues such as nutrients and growth factors is of vital importance to all living cells. Pathways have therefore evolved which can sense the extracellular status, transmit a signal through the cell and affect gene expression, which ultimately enables adaptation. LÄS MER
2. Water Quality and Optical Properties of Swedish Lakes and Coastal Waters in Relation to Remote Sensing
Sammanfattning : Semi-analytical models for remote sensing of water quality parameters need to be parameterized with specific inherent optical properties. In this thesis, data on specific inherent optical properties of Swedish lakes and coastal waters is presented. Also, the problems of measuring in situ spectral backscattering are addressed. LÄS MER
3. Genetics of Two Mendelian Traits and Validation of Induced Pluripotent Stem Cell (iPSC) Technology for Disease Modeling
Sammanfattning : Novel technologies for genome analysis have provided almost unlimited opportunities to uncover structural gene variants behind human disorders. Whole exome sequencing (WES) is especially useful for understanding rare Mendelian conditions, because it reduces the requirements for a priori clinical data, and can be applied on a small number of patients. LÄS MER
4. Poly(A)-specific Ribonuclease (PARN) : Structural and Functional Studies of Poly(A) Recognition and Degradation
Sammanfattning : Regulation of mRNA degradation is a powerful way for the cell to regulate gene expression. A critical step in eukaryotic mRNA degradation is the removal of the poly(A) tail at the 3'-end of the mRNA. LÄS MER
5. Translational Research of Mendelian Disorders : Applications of Cutting-Edge Sequencing Techniques and Molecular Tools
Sammanfattning : Up to 8% of all live-born children are affected with a congenital disorder. Some are Mendelian disorders of known etiology, but many are of undetermined genetic cause and mechanism, limiting diagnosis and treatment. LÄS MER