Sökning: "nicotinic acid"

Visar resultat 6 - 10 av 25 avhandlingar innehållade orden nicotinic acid.

  1. 6. Glutamatergic mechanisms in schizophrenia : role of endogenous kynurenic acid

    Författare :Linda K Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid, a tryptohan metabolite synthesised in astrocytes, is an endogenous antagonist at glutamate receptors, in particular it blocks the glycine site of the (NMDA)-receptor, and at the a7* nicotinic receptor. The compound has been found to be elevated in the cerebrospinal fluid (CSF) as well as in the postmortem prefrontal cortex of patients with schizophrenia. LÄS MER

  3. 7. Neural control of colonic epithelial transport, motility and permeability in vivo. An experimental study in anaesthetized rats

    Författare :Ying Sun; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enteric nervous system; colonic motility; transmural potential difference; net; fluid transport; permeability; bile acid; nitric oxide; inflammatory bowel disease;

    Sammanfattning : Colonic dysfunction may result in diarrhoea, abdominal pain or constipation, andinflammatory bowel disease, bile acid malabsorption and particularly irritable bowelsyndrome are very common disorders. The role of the enteric nervous system (ENS) inthese diseases is largely unknown. LÄS MER

  4. 8. Simulating Functional Cycles and Drug Modulation in Ligand-gated Ion Channels

    Författare :Yuxuan Zhuang; Erik Lindahl; Grace Brannigan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ion channels; molecular dynamics; markov state model; lipid modulation; nicotinic receptor; protein conformational transitions; Biophysics; biofysik;

    Sammanfattning : Understanding the intricate motions and conformational changes that govern biological processes remains a fascinating and challenging endeavor. The research presented in this thesis aims to elucidate the dynamic processes underlying biological functions, specifically focusing on the dynamics of pentameric ligand-gated ion channels (pLGICs), which play a crucial role in signal transduction within the brain. LÄS MER

  5. 9. Influence of kynurenic acid on dopamine neurotransmission : implications for schizophrenia

    Författare :Alexandra Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid (KYNA) belongs to the kynurenines, a group of metabolically related compounds derived from the amino acid tryptophan. It is an antagonist of glutamate- and α7 nicotinic acetylcholine (α7nACh) receptors. Increased levels of KYNA have been observed in the cerebrospinal fluid and postmortem brains of patients with schizophrenia. LÄS MER

  7. 10. Paracellular permeability of intestinal epithelia.An in vivo study

    Författare :Britt-Marie Fihn; Göteborgs universitet; []
    Nyckelord :paracellular permeability; intestinal epithelia; deoxycholic acid; cholera toxin; glucose absorption; water transport;

    Sammanfattning : Aim: Investigate the importance of paracellular transport of water and solutes during physiological and pathophysiological conditions. Methods: The transport of small water-soluble inert permeability markers, was studied in jejunum and colon in anesthetized rats and cats during normal conditions and during exposure to cholera toxin (CT) and deoxycholic acid (DCA). LÄS MER