Sökning: "nicotinic acid"
Visar resultat 21 - 25 av 25 avhandlingar innehållade orden nicotinic acid.
21. Brain glycine receptors as a common target for alcohol and the relapse-preventing drug acamprosate - a preclinical study
Sammanfattning : Alcohol abuse and dependence make up the most prevalent categories of substance use disorders in the world. Converging evidence from the current research group has identified two receptor populations, the glycine (GlyRs) and nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine system, as two potentially important targets for the development of new medication to treat alcohol dependence. LÄS MER
22. Metabolic roles of adenosine : studies using genetically modified mice and transfected cells
Sammanfattning : The aim of this thesis was to further investigate the metabolic roles of adenosine. The endogenous nucleoside adenosine acts by binding to the four adenosine receptors, A1R, A2AR, A2BR and A3R. The A1R is the adenosine receptor that has been proposed to be the one most involved in metabolism. LÄS MER
23. Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems - Methods and Applications in Drug Development
Sammanfattning : Mathematical models based on ordinary differential equations (ODEs) are commonly used for describing the evolution of a system over time. In drug development, pharmacokinetic (PK) and pharmacodynamic (PD) models are used to characterize the exposure and effect of drugs. LÄS MER
24. Molecular mechanisms of HLA associations with myasthenia gravis
Sammanfattning : Myasthenia gravis (MG) is a neuromuscular disease characterised by muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR). MG has a complex pattern of inheritance and several genetic and environmental factors are important in conferring susceptibility to the disease. LÄS MER
25. Nerve injury induced pain and spinal cord stimulation
Sammanfattning : Chronic neuropathic pain caused by injury to or disease in the nervous system is relatively common and results in major suffering, poor quality of life and incapacity. Such pain is a therapeutic challenge because a considerable portion of the patients fails to benefit from pharmacotherapy. LÄS MER