Sökning: "nicotine withdrawal"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden nicotine withdrawal.

  1. 1. Acute and chronic effects by stimulants on behavior and striatal neurotransmission in the rat

    Författare :Amir Lotfi Moghaddam; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; withdrawal; nicotine; amphetamine; striatum; GABA; glutamate; dopamine; sensitization; locomotor activity;

    Sammanfattning : Nicotine and amphetamines are the most widely abused stimulants. The main aim of the studies in this thesis was to investigate how these two drugs of abuse affect distinct regions of the rat brain involved in development of habitual and compulsive behavior, namely subregions of striatum in the rat. LÄS MER

  3. 2. Nicotine sensitization and the effects of extended withdrawal - behavioral, neurochemical and electrophysiological studies in the rat

    Författare :Julia Morud; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Abstinence; Dopamine; Elevated plus-maze; GABA; Inhibitory control; Nicotine; Nucleus accumbens; Sensitization;

    Sammanfattning : Tobacco use is one of the primary factors for global burden of disease and often results in life-long nicotine addiction, only a small percentage users are able to maintain cessation. The life-long addiction together with a high relapse risk might be connected to drug-induced altered neural circuits. LÄS MER

  4. 3. Neurobiological basis of the nicotine withdrawal reaction : an experimental analysis

    Författare :Bengt E Hildebrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :rat; nicotine; nicotine withdrawal; behavior; locomotor activity; microdialysis; intracerebral injections; mesolimbocortical; dopamine; ventral tegmental area; nucleus accumbens; amygdala; immediate-early genes; c-fos;

    Sammanfattning : The mesolimbocortical dopamine (DA) system is pivotal for the mediation of the reinforcing effects of many dependence-producing drugs. It consists of cell bodies in the ventral tegmental area (VTA) that project to e.g. the nucleus accumbens (NAC), the central nucleus of amygdala (CNA) and the medial prefrontal cortex. LÄS MER

  5. 4. Novel pharmacological treatment alternatives for nicotine dependence

    Författare :Nina Lindblom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nicotine; dependence; withdrawal; reinstatement; smoking; active immunisation; immunoconjugate; vaccine; dopamine stabiliser; - -DS121; dopamine; nucleus accumbens; intra cranial selfstimulation;

    Sammanfattning : Smoking has been identified as the single largest preventable cause of morbidity and premature death in the developed world. Despite the well known health risks associated with smoking the number of smokers are still rising globally. LÄS MER

  7. 5. Telephone support for smoking cessation : the Swedish example

    Författare :Tanja Tomson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Quitline; smoking cessation; cost-effectiveness; withdrawal; symptoms; Sweden;

    Sammanfattning : Background: Tobacco is a major public health problem that needs to be addressed. The Swedish quitline is a telephone-based free-of-charge tobacco cessation service. Objective: To study the effectiveness and the cost-effectiveness of the Swedish quitline. LÄS MER