Sökning: "new drugs"

Visar resultat 1 - 5 av 939 avhandlingar innehållade orden new drugs.

  1. 1. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers

    Författare :Staffan Tavelin; Per Artursson; Staffan Tavelin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; intestinal epithelium; tight junctions; cell culture; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. LÄS MER

  2. 2. The international diffusion of new chemical entities : A cross-national study of the determinants of differences in drug lag

    Författare :Fredrik Andersson; Linköpings universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; International diffusion; Drug Jag; New chemical entities; Drugs; Determinants of diffusion; Econometric analysis; Cross-national; NCEs; INTERDISCIPLINARY RESEARCH AREAS; TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN;

    Sammanfattning : The two main objectives of this thesis are to make a general contribution to the understanding of the international diffusion of new chemical entities (NCEs) and to improve the research methods by applying econometric methodology.The study is based on a data base including all 553 NCEs introduced in Sweden during the period 1960-1987 and their introductions in France, West Germany, Italy, the United Kingdom, the United States and Norway. LÄS MER

  3. 3. Potential New Drugs in Lymphoma

    Författare :Maryam Delforoush; Gunilla Enblad; Mattias Berglund; Christina Drott; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphoma; diffuse large B-cell lymphoma; DLBCL; picropodophyllin; PPP; J1; melflufen; prodrug; cancer therapeutics; alkylating agents; b-AP15; proteasome inhibitors; DUB inhibition; UCHL5; USP14;

    Sammanfattning : Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). LÄS MER

  4. 4. Making drugs ethnic : Khat and minority drug use in Sweden

    Författare :Johan Nordgren; Malmö högskola; []
    Nyckelord :Drug use; Khat; Ethnicity; Culture; Discourse analysis;

    Sammanfattning : The aim of this dissertation is to study how discourses and problem representations have made some drugs and some forms of drug use into “ethnic problems” in Sweden and in Scandinavia. The primary example of such a process discussed in the dissertation concerns the use of the psychoactive and criminalized plant khat. LÄS MER

  5. 5. Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs

    Författare :Susanne Römsing; Yngve Bergqvist; Åsa Emmer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; african trypanosomiasis; melatonin; malaria; antiretroviral drugs; lumefantrine; tafenoquine; lamivudine; nevirapine; zidovudine; sampling paper; dried blood spots; capillary blood; antimalarial drugs; solid-phase extraction; liquid chromatography; Chemistry; Kemi; Analytical Chemistry; Analytisk kemi;

    Sammanfattning : This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. LÄS MER