Sökning: "nevus"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet nevus.

  1. 1. Malignant melanoma-Risk factors and the CDKN2A mutation in relation to phenotypes and other cancers

    Författare :Kari Nielsen; Lund Dermatologi och venereologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; clinically atypical nevus; nevus; CDKN2A; melanoma; risk factors; sunbed; UVR;

    Sammanfattning : Background: Cutaneous malignant melanoma (CMM) is an increasingly common cancer in fair-skinned people. The purpose of this thesis was to study high-risk patients with multiple tumours including a CMM, high-risk families with the unique Swedish germline mutation in CDKN2A(113insArg), as well as study risk factors for CMM in women. LÄS MER

  3. 2. Cutaneous malignant melanoma : aspects on prevention

    Författare :Mia Bergenmar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Melanoma; Early detection; Prevention; Information; Dysplastic Nevus Syndrome; Knowledge; UV-exposure;

    Sammanfattning : The general aims of the present thesis were to delineate factors of importance for prevention of cutaneous malignant melanoma (CMM). Three samples of patients with CMM, one sample of patients with dysplastic nevus syndrome (DNS) and a sample from the general population were studied. LÄS MER

  4. 3. Malignant melanoma of the vulva

    Författare :Boel Ragnarsson Olding; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malignant melanoma; Vulvar melanoma; mucosal melanoma; epidemiology; amelanotic melanoma; pre-existing nevus; N-Ras mutation; TP53 mutation;

    Sammanfattning : From a consecutive, nationwide series of 219 females with primary vulvar malignant melanomas diagnosed in Sweden during 1960 to 1984 and followed up until 1994, we analyzed epidemiological, clinical, histopathological, prognostic and molecular genetic data. The age-standardized incidence among these patients, 75 % of whom were 60 years old or more, decreased by 3. LÄS MER

  5. 4. Analysis of Sun-Damaged Skin and Epidermal p53 Clones

    Författare :Helena Bäckvall; Nicole Basset-Seguin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Patologi; Pathology; Patologi; Pathology; patologi;

    Sammanfattning : Sun-damaged skin is a relevant target tissue for studying the development of skin cancer. The aim of the present study was to investigate the epidermal response to ultraviolet radiation (UVR) in human skin in vivo and in vitro and to explore the mutagenic effect of UVA. LÄS MER

  7. 5. Identification and clinical evaluation of senescence-associated markers to distinguish melanocytic nevi from melanomas

    Författare :Kyriakos Orfanidis; Ingrid Synnerstad; Jakob Wikström; John Paoli; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; senescence; nevi; melanoma; melanocytes; fibroblasts; ultraviolet UV radiation;

    Sammanfattning : Melanoma is a form of cancer that develops in melanocytes. While it represents only 5% of skin malignancies, it is the most aggressive and lethal. Benign proliferation of these cells form the melanocytic nevi. The definitive diagnosis of melanocytic nevi or melanoma lesions is histopathologic. LÄS MER