Sökning: "neutralising antibodies"

Visar resultat 1 - 5 av 29 avhandlingar innehållade orden neutralising antibodies.

  1. 1. Glycoprotein B of human cytomegalovirus : target for neutralising antibodies, ligand for cellular receptors, inducer of autoimmunity?

    Författare :Michel Silvestri; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CMV; HCMV; gB; autoimmunity; cross-reactivity; epitope analysis electrochemiluminescence; heparin; heparan sulphate; neutralising antibodies;

    Sammanfattning : Human cytomegalovirus (HCMV), a member of the Herpesviridae, is widespread in humans, causing persistent infections mostly without any clinical symptoms. However in immunosuppressed individuals HCMV still represents a significant factor in morbidity, why there is clearly a need for effective therapy and prophylaxis against HCMV infection. LÄS MER

  3. 2. Haemophilia B - Diagnostic Insights, Genetic Aspects and Clinical Outcomes

    Författare :Kristina Kihlberg; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Coagulation factor IX; Haemophilia B; Haemophilia A; F9 variant; Assay discrepancy; Chromogenic assay; One-stage assay; Bleeding disorders; Quality of life; Immune tolerance induction; Non-neutralising antibodies; Inhibitors; Treatment Adherence; Arthropathy;

    Sammanfattning : Haemophilia B (HB) is a rare inherited bleeding disorder caused by the deficiency of coagulation factor IX (FIX). The major clinical issues are bleedings, often targeting the joints, and the development of neutralising antibodies, i.e. inhibitors, to the FIX replacement therapy. LÄS MER

  4. 3. Monoclonal antibodies and cytokines for therapy of patients with advanced colorectal carcinoma : a clinical and immunological study

    Författare :Anna-Lena Hjelm Skog; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Colorectal carcinoma; Monoclonal antibodies; IL-2; IFN-[alpha]; GM-CSF; cytokine antibodies; neopterin; sIL-2R; immune suppression;

    Sammanfattning : There is a great need for developing and improving treatment alternatives in colorectal carcinoma (CRC). The tumour associated antigen (TAA) GA733/CO17-1A is expressed by more than 90% of all CRCs, on the majority of both primary and metastatic CRC cells. LÄS MER

  5. 4. HIV-2 and SIV vaccine studies in macaques : with emphasis on humoral immune responses

    Författare :Charlotta Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Vaccines; HIV-2; SIV; macaques; adjuvant; immune response; antibodies; neutralising antibodies; cell-mediated immunity; T-cell proliferation; CTL;

    Sammanfattning : This thesis describes the evaluation of HIV vaccines candidates in the HIV-2 or SIV monkey models. The immunogenicity and protective efficacy of the vaccines were investigated. Furthermore, correlates to protective immunity were sought. LÄS MER

  7. 5. Studies on HIV-2 antibody mediated neutralisation, coreceptor usage and in vivo tropism

    Författare :Andreas Mörner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-2; neutralising antibodies; V3; combinatorial library; phage display; Fab fragment; coreceptor; CCR5; CXCR4; HIV encephalitis; macrophages microglia;

    Sammanfattning : Human immunodeficiency virus type 2 (HIV-2) is the second virus that causes AIDS in humans. It has a genetic identity with HIV-1 of 40-60% and similar genetic organisation and biological properties, but the two viruses are distinguished certain features. LÄS MER