Sökning: "neurturin NTN"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden neurturin NTN.

  1. 1. Neuroprotective and regenerative actions of GDNF and neurturin on nigral dopamine neurons in rat models of Parkinson’s disease – Prospects for clinical use of neurotrophic factors in neurodegenerative disorders

    Författare :Carl Rosenblad; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; neuropsychology; Neurology; striatum; substantia nigra; dopamine; GDNF; neurturin; sprouting; neuroprotection; forelimb akinesia; rotation; tyrosine hydroxylase; transplantation; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Parkinson’s disease is characterized by progressive degeneration of the nigrostriatal dopamine system, which results in tremor, rigidity, akinesia and postural abnormalities. New therapeutic strategies are aimed at halting the neurodegenerative process or restoring the system by transplantation of fetal dopamine neurons. LÄS MER

  3. 2. Glial cell line-derived neurotrophic factor : expression patterns, neuronal transport, regulation, effects, and receptor dependence

    Författare :Andreas C Tomac; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :glial cell line-derived neurotrophic factor GDNF ; neurturin NTN ; persephin PSP ; c Ret proto oncogene Ret ; GPI-linked receptors for the GDNF ligand family GFRas ; transforming growth factor-B TGFB ; Parkinson s disease PD ; dopaminergic DA neurons;

    Sammanfattning : Background: The mammalian nervous system depends upon trophic proteins for survival, growth and adult maintenance. These trophic factors have also been considered as potential therapeutic agents for treating human neurodegenerative disorders. LÄS MER

  4. 3. Expression and function of GDNF family ligands and receptors in the nervous system

    Författare :Åsa Mikaels; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The search for novel neurotrophic factors promoting dopamine uptake and the survival of central dopaminergic neurons led to the discovery of a novel neurotrophic factor termed glial cell-line derived neurotrophic factor (GDNF). GDNF, neurturin (NTN), artemin (ART) and persephin (PSP) belong to the GDNF family ligands, and are potent survival-promoting factors for subsets of central and peripheral neurons. LÄS MER

  5. 4. GDNF family ligands and neural stem cells in Parkinson's disease

    Författare :Peter Åkerud; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson's disease (PD) is a very common neurodegenerative disorder, characterized by a progressive degeneration of mainly nigrostriatal and mesolimbic dopaminergic neurons leading to tremor, rigidity and hypokinesia, the classical symptoms of the disease. Degeneration of noradrenergic neurons of the locus coeruleus are also involved in the progression of the disease, causing dementia and depression. LÄS MER

  7. 5. Structure-function studies of GDNF and other members of the TGF-beta superfamily

    Författare :Susanna Eketjäll; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The glial cell line-derived neurotrophic factor (GDNF) family is a distant subclass of the TGF-beta superfamily. The GDNF family of ligands, consisting of GDNF, neurturin (NTN), artemin (ART) and persephin (PSP), are potent survival and differentiation factors for neurons in the central and peripheral nervous systems. LÄS MER