Sökning: "neurotrophins"

Visar resultat 6 - 10 av 56 avhandlingar innehållade ordet neurotrophins.

1. 6. Studies on neurotrophins in inflammatory pulmonary diseases

   Författare :Charlotta Dagnell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Asthma, sarcoidosis and chronic obstructive pulmonary disease (COPD) are inflammatory pulmonary diseases, all being characterized by tissue inflammation, tissue damage (airway remodeling) and loss of lung function. In order to increase possibilities to find new biomarkers, drug targets and better treatment options for the patients, further research on the underlying mechanisms driving the inflammation and airway remodeling in these diseases are required. LÄS MER

3. 7. Evolutionary and structure-function studies of neurotrophins

   Författare :Klas Kullander; Uppsala universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : .... LÄS MER

4. 8. Specificity of neurotrophins in the nervous system : a genetic approach to determine receptor engagement by neurotrophins

   Författare :Karin Agerman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The classical neurotrophic factor hypothesis describes the neurotrophins as retrograde signalling factors supporting the survival of postmitotic neurons during the development. Knock-out mice for the neurotrophins and/or their receptors have been generated and their analyses gave new insights in the temporal expression and particular functions of these factors during development. LÄS MER

5. 9. Studies on neuroimmune interactions in allergic inflammation with focus on neurotrophins

   Författare :Cecilia Kemi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Allergic inflammation; neuroimmune interaction; neurotrophins; smooth muscle cells; stress;

   Sammanfattning : Allergic asthma is a chronic airway disease characterized by an eosinophilic inflammation, bronchoconstriction, increased mucus production and bronchial hyperreactivity. The disease involves several mediators and cell types and is associated with a Th2-mediated immune response. Stress is a factor reported to deteriorate the allergic inflammation. LÄS MER

7. 10. Development requirements of neurotrophins in the mammalian nervous system

   Författare :Wael M Elshamy; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The survival of the mammalian peripheral nervous system neurons has long been known to depend on neurotrophic factor support during the period of programmed cell death. In fact this was the original hypothesis, put forward after the discovery of the prototype, nerve growth factor (NGF). LÄS MER