Sökning: "neurotrophins"

Visar resultat 21 - 25 av 56 avhandlingar innehållade ordet neurotrophins.

  1. 21. Exploration of 3D cell-bioscaffolds for advancing CNS restorative therapy

    Författare :Marina Castro Zalis; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell therapy; CNS; nanofiber scaffolds; electrospining; extracellular matrix; neurotrophins; hNPCs; RPNCs;

    Sammanfattning : .... LÄS MER

  3. 22. Spinal cord grafts : interaction with cografts and effects of trophic factors

    Författare :Katarzyna Trok; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cord injury; spinal cord transplants; regeneration; GDNF; neurotrophins; CNTF; 5HT; immunohistochemistryKatarzyna Trok; 1996ISBN 91-6;

    Sammanfattning : Spinal cord injury is common in the modern society, often afflicts young individuals, and often has devastating consequences. The present work studies possibilities to obtain better conditions for regeneration of the transected spinal cord in rats, conditions under which spinal cord grafts are able to establish structural and functional connections with "natural" targets, and effects of a series of neurotrophic factors on spinal cord graft survival and growth. LÄS MER

  4. 23. Neurotrophic factors and their receptors structure-function relationships and signalling mechanisms

    Författare :Mikael Ryden; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :neurotrophins; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; p75 neurotrophin receptor; neuroblastoma; serinethreonine kinase receptors;

    Sammanfattning : Background: The development, survival and maintenance of the vertebrate nervous system requires the continuous supply of a set of polypeptides termed neurotrophic factors. Among these, the neurotrophins (NTs) and members of the transforming growth factor-B (TGF-B) superfamily have raised substantial hopes for future clinical applications. LÄS MER

  5. 24. Neurothrophins in the development of the gustatory system and teeth

    Författare :Christopher A Nosrat; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gustation; gustatory; taste buds; neurotrophins; NGF; BDNF; NT-3; NT-4; GDNF; GFRalpha-l; GFRalpha-2; knockout; innervation; development; tooth; tooth development; odontogene sis. Christopher A. Nosrat; 1997;

    Sammanfattning : Flavors of taste are detected by a set of microscopical cellular aggregates called the taste buds, present in different arrangements on the upper surface of the tongue and other areas in the mouth. Taste buds are chemosensors that can detect different taste qualities such as sweet, sour, bitter, salt and umami. LÄS MER

  7. 25. Regulation of neurotrophic signaling molecules in motor neurons, primary sensory neurons and target tissues in senescence

    Författare :Yu Ming; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aging; dorsal root ganglion; spinal cord; muscle; neurotrophins; GFRalpha; Ret; FGF-2; gp 130; CNTF; LIF; IL-6; receptors; protein; mRNA; glia; axon dystrophy; demyelination.;

    Sammanfattning : A hallmark of senescence is sensorimotor impairment, characterized by gait disturbance, deficits in postural control, and muscle weakness. The object of this thesis work was to elucidate some of the molecular basis underlying these disturbances, mainly referring to the occurrence of characteristic changes in gene-expression pattern, especially, alterations in trophic signaling associated with the phenotypic changes seen in motoneurons as well as primary sensory neurons and target muscles during aging. LÄS MER