Sökning: "neurotrophin"

Visar resultat 16 - 20 av 64 avhandlingar innehållade ordet neurotrophin.

  1. 16. Megencephaly, significance, biology and identification of a genetic cause

    Författare :Susanna Petersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Megalencephaly; brain; mceph; ion-channel; DNA; mutation; truncation; frameshift; seizure; plasticity; neurotrophin; growth factor; neuropeptide; positional cloning;

    Sammanfattning : Enlarged brain is termed megencephaly or megalencephaly, and is defined as a brain volume above the 98th percentile. It is a major sign in several neurological diseases with symptoms ranging from very mild to lethal, including mental retardation, low intelligence, motoric and neurological disturbances, seizures and dysmorphic features. LÄS MER

  3. 17. Genetic aspects on schizophrenia and cerebrospinal fluid monoamine metabolites : focus on association studies with candidate genes

    Författare :Erik Jönsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :association study; schizophrenia; DNA polymorphisms; dopamine receptors DRD2; DRD3; DRD4 ; tyrosine hydroxylase; tryptophan hydroxylase; catechol-O-methyltransferase; neurotrophin-3; ciliary neurotrophic factor; healthy subjects; cerebrospinal fluid;

    Sammanfattning : Schizophrenia is a syndrome with psychotic symptoms. The pathogenesis of schizophrenia most likely reflects brain abnormalities and heritable components are present. The principal objective of the present thesis was to investigate some possible genetic influences in the genesis or pathophysiology of schizophrenia. LÄS MER

  4. 18. Spinal motoneurones and the bulbospinal serotonininergic system in aged rats with behavioral deficits

    Författare :Hans Johnson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :aging; behavior; immunohistochemistry; in situ hybridisation; motoneuron; CGRP; axotorny; GAP-43; neurotrophin receptors; degeneration; axon dystrophy; 5HT TRH; SP; 5HLkA; AADC; serotonintransporter protein; fluoxetine; L-5-HTP;

    Sammanfattning : The expression of neuropeptides, growth-related proteins and neurotrophin receptors were studied in motoneurons of young adult rats and in aged rats with symptoms of neuromuscular incapacities. Also studied were aging-related changes in the descending serotoninergic (5HT) bulbospinal system which constitutes a major afferent pathway to spinal motoneurons. LÄS MER

  5. 19. Neurothrophins during development : overexpression in neural stem cells

    Författare :Thomas Ringstedt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The neurotrophins constitute a family of secreted, diffusible peptide factors that are widely expressed in the developing nervous system. They are known to function as survival factors in the peripheral nervous system during the period of naturally occurring cell death, to promote axonal outgrowth and to affect neurotransmitter expression of responsive cells. LÄS MER

  7. 20. Neurotrophic and immune regulatory factors in neuroinflammation

    Författare :Alexander W Gielen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neurotrophins; EAE; MS; TIM; Neuroprotection;

    Sammanfattning : Inflammatory reactions in the nervous system act as a double-edged sword. On the one hand, neuroinflammation can have very devastating effects on the nervous system, leading to neurological dysfunction. LÄS MER