Sökning: "neuropsychology Neurology Neurologi neuropsykologi neurofysiologi neurophysiology dyskinesia L-DOPA"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden neuropsychology Neurology Neurologi neuropsykologi neurofysiologi neurophysiology dyskinesia L-DOPA.

1. 1. Assessment of Graft Effects and Function in Cell Replacement Therapy for Parkinson's Disease

   Författare :Peter Hagell; Äldres hälsa och personcentrerad vård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; measurement; psychometrics; perceived health; dyskinesias; assessment; striatum; positron emission tomography; dopamine; Parkinson s disease; transplantation;

   Sammanfattning : This explorative study aimed to apply, develop, and evaluate assessment methods at various levels in cell replacement therapy for Parkinson’s disease (PD). Observed motor effects in five grafted patients support that timed motor tasks and clinical ratings of parkinsonism are able to monitor motor function, but their psychometric properties need further attention. LÄS MER

3. 2. Transcriptional dysregulation in L-DOPA-induced dyskinesia

   Författare :Malin Andersson; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; neurofysiologi; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; CREB; jun; fos; immediate early genes; prodynorphin; striatal plasticity; Parkinson s disease; dyskinesia; Klinisk genetik;

   Sammanfattning : This study explores the role of transcriptional regulation important in the development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. In patients with Parkinson’s disease, dyskinesia is one of the most difficult complications of the DA-replacement therapy by L-DOPA. LÄS MER

4. 3. Intracellular signaling and cellular plasticity in a rat model of L-DOPA-induced dyskinesia

   Författare :Jenny Westin; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein synthesis; Nukleinsyror; proteinsyntes; neurofysiologi; Nucleic acids; Neurologi; neuropsykologi; L-DOPA; Dopamine; Neurology; neuropsychology; neurophysiology; Parkinson s disease;

   Sammanfattning : Parkinson's disease (PD) is a neurodegenerative disorder where the midbrain dopaminergic neurons are lost. Presently there is no cure for PD, and the most common treatment is to replace the lost dopamine pharmacologically by administration of the dopamine precursor L-DOPA. LÄS MER

5. 4. Modelling parkinsonian akinesia and dyskinesia in dopamine depleted rodents

   Författare :Martin Lundblad; Basala gangliernas patofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; Neurology; mouse; rat; 6-OHDA; dyskinesia; Parkinson s disease; L-DOPA;

   Sammanfattning : Animal models of Parkinson’s disease and L-DOPA-induced dyskinesia are essential to explore pathophysiological hypotheses and to test new treatment options. There are many different animal models of Parkinson's disease, which differ greatly with respect to species, mechanisms of nigral cell death, and extent of dopamine-dependent motor deficits. LÄS MER

7. 5. Toward a restorative therapy for Parkinson´s disease. Studies on the functional efficacy of intracerebral fetal cell transplants and GDNF delivery

   Författare :Christian Winkler; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; Neurologi; neuropsykologi; neurofysiologi; neurophysiology; dyskinesia; L-DOPA; behaviour; transplantation; neuroprotection; GDNF; substantia nigra; striatum;

   Sammanfattning : Parkinson´s disease is characterized by a progressive degeneration of the nigral dopaminergic system. Treatment of disease symptoms using L-DOPA frequently induces side effects such as L-DOPA-induced dyskinesia. LÄS MER