Avancerad sökning

Visar resultat 1 - 5 av 182 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Cerebral Injury in Perinatal Asphyxia, epidemiological, clinical, neurophysiological and neuromatabolic investigations

   Författare :Kristina Thorngren-Jerneck; Lund Pediatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; Neurology; Pediatri; Pediatrics; S100; EEG; CMRgl; cerebral glucose metabolism; FDG-PET; CP; infant; perinatal asphyxia; hypoxia-ischemia;

   Sammanfattning : Perinatal asphyxia with hypoxic ischemic encephalopathy (HIE) is the most important cause of perinatal mortality and cerebral palsy (CP) in infants born at term. The aim of the thesis was to investigate epidemiology of perinatal asphyxia, and to investigate early clinical neurological symptoms after perinatal asphyxia in relation to cerebral glucose metabolism (CMRgl) measured by 18-FDG-PET, neurophysiological function, some biochemical markers, also in relation to long-term outcome. LÄS MER

3. 2. Pathways linking sleep, neuroimmune signaling and pain: an integrative approach

   Författare :Martin Flores Bjurström; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pain; neuroinflammation; inflammation; glia; central sensitization; cerebrospinal fluid; osteoarthritis; chronic postsurgical pain; groin hernia repair; sleep; sleep disturbance; perioperative; neurophysiology;

   Sammanfattning : Background and objectives: Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there is limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. Study I aimed to investigate whether there are coherent changes in CSF inflammation associated with central sensitization (CS), and to evaluate potential differences in CSF levels of inflammatory mediators between osteoarthritis (OA) patients with disabling pain and pain-free controls. LÄS MER

4. 3. Development of highly biocompatible neuro-electronic interfaces towards monitoring authentic neuronal signaling in the brain

   Författare :Johan Agorelius; NanoLund: Centre for Nanoscience; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; BMI; brain machine interface; Neuro-electronic interface; neurophysiology; brain computer interface; biocompatibility; biocompatible neural interface; neural interface; histology; electrophysiology;

   Sammanfattning : Background: To understand how the neuronal circuits in the brain process information there is a need for novelneuro-electronic interfaces that can interact chronically with brain tissue with minimal disturbance of thephysiological conditions in the tissue, in awake and freely moving animals. For this, there is a need for implantableneuro-electronic interfaces that are mechanically compliant with the tissue and that can remain positionally stablewith respect to the neurons, despite the continuous micromotions in the brain. LÄS MER

5. 4. Stroke in geriatric patients - Aspects of depression, cognition and motor activity

   Författare :Berit Agrell; Geriatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stroke; laterality; rating scales; motoractivity; aphasia; neglect; disability; depression; cognition; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : Six depression rating scales, GDS, Zung, CES-D, CPRS-D and Cornell, were compared in 40 patients. The validity was good for all scales except for the Cornell scale. A comprehensive investigation was done in 116 elderly stroke patients. There was no difference in prevalence and severity of post-stroke depression in relation to side of lesion. LÄS MER

7. 5. Aspects of proteinase-activated receptor-2: A sensor of enzymatic activity at the cell surface

   Författare :Anna-Karin Alm; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; Neurology; endometrium.; coagulation; signalling; proteinase; G-protein; cell; receptor; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : Information about extracellular proteolytic activity is transduced to the cell by a transmembrane G-protein coupled receptor subfamily. These receptors are activated by proteolytic cleavage in the extracellular amino-terminal domain and are thus termed proteinase-activated receptors (PARs). LÄS MER