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Visar resultat 1 - 5 av 452 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Search for Biomarkers in ALS and Parkinson's Disease : Positron Emission Tomography and Cerebrospinal Fluid Studies

   Författare :Anders Johansson; Håkan Askmark; Lennart Persson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyotrophic lateral sclerosis; ALS; Parkinson’s disease; cerebrospinal fluid; positron emission tomography; vascular endothelial growth factor; fibroblast growth factor 2; proteomics; Fourier transform ion cyclotron resonance mass spectrometry; deprenyl-D2; PIB; FDG; L-[β11C]-DOPA; Neurology; Neurologi; Neurology; neurologi;

   Sammanfattning : New biomarkers are needed to improve knowledge about pathophysiology, in order to provide earlier correct diagnosis and to follow disease progression of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). The aim of this thesis was to find new biomarkers for these diseases. LÄS MER

3. 2. Metabolomics studies of ALS : a multivariate search for clues about a devastating disease

   Författare :Anna Wuolikainen; Peter M Andersen; Henrik Antti; Stefan L Marklund; Thomas Moritz; Thomas Hankemeier; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyotrophic lateral sclerosis ALS ; motor neuron disease; Lou Gehrig’s disease; human disease; CSF; biomarkers; metabolomics; metabonomics; chemometrics; design of experiments; multivariate analysis.; Neurology; Neurologi; Neurology; neurologi;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS), also known as Charcot’s disease, motor neuron disease (MND) and Lou Gehrig’s disease, is a deadly, adult-onset neurodegenerative disorder characterized by progressive loss of upper and lower motor neurons, resulting in evolving paresis of the linked muscles. ALS is defined by classical features of the disease, but may present as a wide spectrum of phenotypes. LÄS MER

4. 3. Curing Multiple Sclerosis : How to do it and how to prove it

   Författare :Joachim Burman; Jan Fagius; Angelica Loskog; Sara Mangsbo; Paulo Muraro; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; cerebrospinal fluid; cytokines; hematopoietic stem cell transplantation; immunology; magnetic resonance imaging; multiple sclerosis; neuroimmunology; neurology; Neurology; Neurologi;

   Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for multiple sclerosis (MS) with now more than 600 documented cases in the medical literature. Long-term remission can be achieved with this therapy, but when is it justified to claim that a patient is cured from MS? In attempt to answer this question, the outcome of the Swedish patients is described, mechanisms behind the therapeutic effect are discussed and new tools for demonstration of absence of disease have been developed. LÄS MER

5. 4. 11C Molecular Imaging in Focal Epilepsy

   Författare :Torsten Danfors; Eva Kumlien; Jens Sörensen; Elisabeth Ronne-Engström; Juha Rinne; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; positron emission tomography; methionine; NK1; substance p; flumazenil; deprenyl; pk11195; phosphoimager; autoradiography; TBI; traumatic brain injury; iron chloride; ferrous chloride; Neurology; Neurologi; Radiology; Radiologi;

   Sammanfattning : Epilepsy is a common neurological disease affecting 6 million people in Europe. Early prevention and accurate diagnosis and treatment are of importance to obtain seizure freedom. In this thesis new applications of carbon-11-labelled tracers in PET and autoradiographic studies were explored in focal epilepsy. LÄS MER

7. 5. Headache in Schoolchildren : Epidemiology, Pain Comorbidity and Psychosocial Factors

   Författare :Katarina Laurell; Matti Sillanpää; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Children; Headache; Tension-type headache; Migraine; Prevalence; Incidence; Prognosis; Pain; Psychosocial factors; Neurovetenskap; Neurology; Neurologi;

   Sammanfattning : Headache is the most frequently reported pain in children and is associated with missed schooldays, anxiety, depressive symptoms and various physical symptoms. A secular trend of increasing headache prevalence has been suggested. Few studies have focused on tension-type headache among children from the general population. LÄS MER