Sökning: "neuroinflammation"

Visar resultat 16 - 20 av 121 avhandlingar innehållade ordet neuroinflammation.

1. 16. Biomarkers for Better Understanding of the Pathophysiology and Treatment of Chronic Pain : Investigations of Human Biofluids

   Författare :Anne-Li Lind; Torsten Gordh; Masood Kamali-Moghaddam; Jonas Bergquist; Eva Kosek; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chronic pain; neuropathic pain; lumbar radicular pain; amyotrophic lateral sclerosis; radiculopathy; fibromyalgia; pathophysiology; spinal cord stimulation; mechanism of action; disc herniation; cerebrospinal fluid; plasma; biomarker; human; protein; chemokines; cytokines; inflammation; neuroinflammation; mass spectrometry; proximity ligation assay; proximity extension assay; antibody suspension bead array; protein profiling; molecular medicine; personalized medicine; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Chronic pain affects 20 % of the global population, causes suffering, is difficult to treat, and constitutes a large economic burden for society. So far, the characterization of molecular mechanisms of chronic pain-like behaviors in animal models has not translated into effective treatments. LÄS MER

3. 17. The role of microglia in Alzheimer's disease - Investigating mechansims regulating amyloid-β clearance

   Författare :Carl-Henrik Andersson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microglia; neuroinflammation; amyloid-beta; Alzheimer s disease; genetic association; biomarker; cerebrospinal fluid; zebrafish; clearance; in vivo imaging;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia today. The disease is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, accompanied by a progressive neurodegeneration leading to memory loss. LÄS MER

4. 18. Neurochemical and cognitive aftermaths of surgery - studies on short- and long-term effects of surgery and anesthesia

   Författare :Mattias Danielsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anesthesia; blood-brain barrier; brain amyloidosis; cardiac surgery; orthopedic surgery; inflammation; neuroinflammation; neuronal damage; cognitive decline; postoperative cognitive dysfunction;

   Sammanfattning : Background: Each year, around the world, more than 230 million patients have surgery. Improvements in healthcare have resulted in older and sicker patients undergoing surgical interventions. As a result, surgical safety has be-come a global public-health concern. LÄS MER

5. 19. Microglial Glutamate Transporters - Regulation of Expression and Possible Physiological Functions

   Författare :Mikael Persson; Göteborgs universitet; []
   Nyckelord :anaphylatoxin; central nervous system; herpes simplex virus; glutamate transport; glutathione; GLT-1; lipopolysaccharide; microglia; neuroinflammation; oxidative stress; protection; tumour necrosis factor-alpha;

   Sammanfattning : Microglia are considered as the immunocompetent cells of the central nervous system (CNS). Being the first line of defence, they have prominent roles in monitoring the homeostasis and the extracellular milieu and can rapidly and specifically react to any disturbances such as brain trauma, ischemia, neurodegenerative diseases, or infections. LÄS MER

7. 20. On neuroinflammation in psychotic disorders

   Författare :Carl Sellgren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Neuroinflammation has been implicated in several psychiatric conditions. Based on experimental studies, the glia-derived tryptophan metabolite kynurenic acid (KYNA) may be especially relevant for positive psychotic symptoms and impaired executive functioning. LÄS MER