Sökning: "neurogranin"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet neurogranin.

  1. 1. Candidate biomarkers for synaptic pathology: neurogranin, neuroligins and neurexins in neurodegenerative disorders

    Författare :Elena Camporesi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synaptic dysfunction; Alzheimer’s disease; Biomarkers; Neurogranin; Neurexins; Neuroligins; Cerebrospinal fluid; Brain tissue;

    Sammanfattning : Synapses are small units through which neurons communicate in the brain. They represent the site of memory formation and cognitive abilities and are thus primarily affected by neurodegenerative diseases such as Alzheimer’s disease (AD), the leading cause of dementia in the elderly population. LÄS MER

  3. 2. The postsynaptic protein neurogranin: a new item in the Alzheimer’s disease biomarker toolbox

    Författare :Hlin Kvartsberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CSF; brain tissue; Alzheimer s disease; biomarker; neurogranin;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia affecting more than 50 million people worldwide today and is characterised by progressive cognitive decline. One of the earliest events in AD, which is also closely related to neuronal loss and the degree of dementia, is synaptic degeneration. LÄS MER

  4. 3. Increasing the interpretability of Alzheimer-related biomarkers: cell- and cerebrospinal fluid-based studies with focus on neurogranin

    Författare :Faisal Hayat Nazir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; biomarker; neurogranin; APP; human iPSCs; CSF;

    Sammanfattning : Biomarkers for Alzheimer’s disease (AD) is a growing field of research. A particularly vibrant field during recent years has been biomarkers for synaptic dysfunction. LÄS MER

  5. 4. Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease

    Författare :Joakim Hertze; Klinisk minnesforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; mild cognitive impairment; white matter lesions; brain reserve; blood-brain barrier; angiogenesis; neuroinflammation; neurogranin; YKL-40; VEGF; IGF; ICAM-1; VCAM-1;

    Sammanfattning : Alzheimer’s disease (AD), the most common cause of dementia, is a growing concern. As the life expectancy increases across the globe, the number of affected people is estimated to reach 100 million by 2050. LÄS MER

  7. 5. Alzheimer's disease : towards a multifaceted approach in neuropathological diagnosis

    Författare :Nenad Bogdanovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; CERAD; neurofibrillary tangles. neuritic plaques; apoE. synaptic proteins; rab3a; synaptophysin; synaptotagmin; GAP-43; neurogranin; neuronal degeneration; optical disector 1998;

    Sammanfattning : The main aim of this study has been to investigate potential neuropathological features which may play an important role in understanding the cognitive dysfunction and in making the final diagnosis of Alzheimer's disease (AD). To establish a reliable diagnosis of AD, standardisation and uniformity of the diagnostic protocols must become mandatory. LÄS MER