Sökning: "neurofilament light chain"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden neurofilament light chain.

  1. 1. Treatment with the monoclonal antibody rituximab in Multiple Sclerosis : a study based on an academic clinical trial

    Författare :Pierre de Flon; Anders Svenningsson; Martin Gunnarsson; Katarina Laurell; Sten Fredrikson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple sclerosis; Rituximab; Cytokines; Immunological profile; Neurofilament light; Treatment satisfaction; neurologi; Neurology;

    Sammanfattning : Background: Multiple sclerosis (MS) is a chronic, inflammatory disease, affecting the central nervous system. A growing number of disease modifying treatment alternatives entails a need for an individualised risk-benefit- convenience analysis in the counselling of patients and methods to monitor the treatment effect, including markers for subclinical inflammation. LÄS MER

  3. 2. Prognostic subtypes in Parkinson’s disease and related disorders. Clinical, genetical, and biochemical markers for long-term social, motor, and cognitive development

    Författare :Emil Ygland Rödström; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; parkinson s disease; prognosis; Neurofilament light chain; clinical subtype; motor phenotype; MAPT R406W mutation; frontotemporal dementia; enthorinal cortex; progressive supranuclear palsy; tau isoform; brain-gut hypothesis; proteoglycan recognition protein; PGLYRP; RUNDC3B;

    Sammanfattning : .... LÄS MER

  4. 3. On HIV-1 infection in the central nervous system

    Författare :Åsa Mellgren; Göteborgs universitet; []
    Nyckelord :HIV-1; antiretroviral therapy; cerebrospinal fluid; neurofilament protein; AIDS dementia complex; neuropsychological test;

    Sammanfattning : HIV-1 (hereafter referred to as HIV) is a neurotropic virus that invades the central nervous system (CNS). The CNS is then susceptible to an acute infection and later to CNS opportunistic diseases and AIDS dementia complex (ADC). HIV does not infect the neurons, and neuropathogenesis is largely mediated by the immune system. LÄS MER

  5. 4. Biomarkers for diagnosis and prognosis in amyotrophic lateral sclerosis

    Författare :Arvin Behzadi; Karin Forsberg; Anton E. Tjust; Anna Wuolikainen; Per Zetterström; Lars-Owe D. Koskinen; Andreas Puschmann; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyotrophic lateral sclerosis; biomarkers; neurofilaments; cytokines; troponin; cystatin C; Neurology; neurologi;

    Sammanfattning : Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by loss of upper and lower motor neurons, leading to paresis, muscle atrophy, and respiratory failure. ALS can be difficult to diagnose and prognosticate early. LÄS MER

  7. 5. Establishment and applications of a multiple sclerosis biobank : analysis of biomarkers and therapeutic complications in MS

    Författare :Ellen Iacobaeus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Biomarkers for disease activity and prognosis in multiple sclerosis (MS) are lacking. We established a MS biobank consisting of paired cerebrospinal fluid samples (CSF) and peripheral blood samples from MS patients and controls. LÄS MER