Sökning: "neurofilament light chain"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden neurofilament light chain.

  1. 1. Treatment with the monoclonal antibody rituximab in Multiple Sclerosis : a study based on an academic clinical trial

    Författare :Pierre de Flon; Anders Svenningsson; Martin Gunnarsson; Katarina Laurell; Sten Fredrikson; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple sclerosis; Rituximab; Cytokines; Immunological profile; Neurofilament light; Treatment satisfaction; neurologi; Neurology;

    Sammanfattning : Background: Multiple sclerosis (MS) is a chronic, inflammatory disease, affecting the central nervous system. A growing number of disease modifying treatment alternatives entails a need for an individualised risk-benefit- convenience analysis in the counselling of patients and methods to monitor the treatment effect, including markers for subclinical inflammation. LÄS MER

  2. 2. Prognostic subtypes in Parkinson’s disease and related disorders. Clinical, genetical, and biochemical markers for long-term social, motor, and cognitive development

    Författare :Emil Ygland Rödström; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; parkinson s disease; prognosis; Neurofilament light chain; clinical subtype; motor phenotype; MAPT R406W mutation; frontotemporal dementia; enthorinal cortex; progressive supranuclear palsy; tau isoform; brain-gut hypothesis; proteoglycan recognition protein; PGLYRP; RUNDC3B;

    Sammanfattning : .... LÄS MER

  3. 3. On HIV-1 infection in the central nervous system

    Författare :Åsa Mellgren; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :HIV-1; antiretroviral therapy; cerebrospinal fluid; neurofilament protein; AIDS dementia complex; neuropsychological test;

    Sammanfattning : HIV-1 (hereafter referred to as HIV) is a neurotropic virus that invades the central nervous system (CNS). The CNS is then susceptible to an acute infection and later to CNS opportunistic diseases and AIDS dementia complex (ADC). HIV does not infect the neurons, and neuropathogenesis is largely mediated by the immune system. LÄS MER

  4. 4. Establishment and applications of a multiple sclerosis biobank : Analysis of biomarkers and therapeutic complications in MS

    Författare :Ellen Iacobaeus; Karolinska Institutet; Karolinska Institutet; []

    Sammanfattning : Biomarkers for disease activity and prognosis in multiple sclerosis (MS) are lacking. We established a MS biobank consisting of paired cerebrospinal fluid samples (CSF) and peripheral blood samples from MS patients and controls. LÄS MER

  5. 5. Biomarkers and Disease Activity in Multiple Sclerosis : A cohort study on patients with clinically isolated syndrome and relapsing remitting multiple sclerosis

    Författare :Irene Håkansson; Jan Ernerudh; Charlotte Dahle; Magnus Vrethem; Jan Lycke; Linköpings universitet; []

    Sammanfattning : This thesis focuses on disease activity in clinically isolated syndrome (CIS) and newly diagnosed relapsing remitting multiple sclerosis (RRMS). The papers are based on data from 41 patients in a prospective longitudinal cohort study. All patients were untreated at baseline. LÄS MER